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SDZ 280 446

Known as: SDZ 280-446, SDZ-280 446, SDZ-280446 
A novel semi-synthetic derivative of cyclosporin and a cyclodepsipeptide with chemo-sensitizing activity. SDZ 280-446 is one of the drug resistance… 
National Institutes of Health

Related topics

Related topics

2 relations
ABCB1 protein, human

Broader (1)

Cyclic Peptides

Papers overview

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Highly Cited
1995
Highly Cited
1995
Decreased biotolerability for ivermectin and cyclosporin a in mice exposed to potent P‐glycoprotein inhibitors
SDZ PSC 833 or SDZ 280‐446 are strong blockers of the function of class 1 mdr gene‐encoded P‐glycoprotein molecules, which were… 
1994
1994
Extent and persistence of P-glycoprotein inhibition in multidrug-resistant P388 cells after exposure to resistance-modifying agents.
The low daunomycin (DAU) retention in P388 cells displaying P-glycoprotein (Pgp)-mediated multidrug resistance (MDR) can be… 
1994
1994
Modulation of human P-glycoprotein epitope expression by temperature and/or resistance-modulating agents.
Three monoclonal antibodies (mAb), MRK16, MM4.17 and MC57, directed against distinct epitopes on the external domain of human P… 
Highly Cited
1993
Highly Cited
1993
Restoration of taxol sensitivity of multidrug-resistant cells by the cyclosporine SDZ PSC 833 and the cyclopeptolide SDZ 280-446.
BACKGROUND Taxol, a promising agent for the treatment of cancer, has entered phase II clinical trials. Nevertheless, it belongs… 
1993
1993
Atypical multi-drug resistance (MDR): low sensitivity of a P-glycoprotein-expressing human T lymphoblastoid MDR cell line to classical P-glycoprotein-directed resistance-modulating agents.
Verapamil, cyclosporin A (CsA), the cyclosporin derivative SDZ PSC 833 and the novel cyclopeptolide SDZ 280-446 were tested for… 
1992
1992
SDZ PSC 833 and SDZ 280–446 are the most active of various resistance‐modifying agents in restoring rhodamine‐123 retention within multidrug resistant P388 cells
Multidrug resistance (MDR) of tumor cells may result from overexpression of P-glycoprotein (Pgp) but may be down-modulated by… 
1992
1992
Expression of P-glycoprotein on normal lymphocytes: enhancement of the doxorubicin-sensitivity of concanavalin A-responding mouse spleen cells by P-glycoprotein blockers.
The in vitro proliferative response of mouse spleen cells (SC) to the T-cell mitogen, concanavalin A (ConA), displays a… 
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