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Channelopathies are disorders caused by abnormal ion channel function in differentiated excitable tissues. We discovered a unique… Expand Randomised trials reported up to Dec 31, 2012, did not confirm that vitamin D supplementation could protect from non-skeletal… Expand The discovery of human pluripotent stem cells (hPSCs), including both human embryonic stem cells and human-induced pluripotent… Expand α‐ and β‐cells express both Nav1.3 and Nav1.7 Na+ channels but in different relative amounts. The differential expression… Expand The human sodium channel family includes seven neuronal channels that are essential for the initiation and propagation of action… Expand The late and persistent sodium current (INa) has been identified as a target for anti‐arrhythmia drugs in patients with heart… Expand Objectives Many antiepileptic drugs (AEDs) prevent seizures by blocking voltage-gated brain sodium channels. However, treatment… Expand Mutations in the sodium channel genes SCN1A and SCN2A have been identified in monogenic childhood epilepsies, but SCN3A has not… Expand Na+‐coupled carboxylate transporters (NaCs) mediate the uptake of tricarboxylic acid cycle intermediates in mammalian tissues. Of… Expand Autism is a psychiatric disorder with estimated heritability of 90%. One-third of autistic individuals experience seizures. A… Expand