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SCN2A wt Allele

Known as: NAC2, EIEE11, SCN2A1 
Human SCN2A wild-type allele is located in the vicinity of 2q24.3 and is approximately 153 kb in length. This allele, which encodes sodium channel… Expand
National Institutes of Health

Related topics

Related topics

8 relations
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 11Homo sapiensIonophore activityLigand Binding
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Broader (1)

SCN2A gene

Papers overview

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Highly Cited
2009
Highly Cited
2009
Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation
The distal end of the axon initial segment (AIS) is the preferred site for action potential initiation in cortical pyramidal… Expand
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Highly Cited
2007
Highly Cited
2007
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
Activation of tetrodotoxin-resistant sodium channels contributes to action potential electrogenesis in neurons. Antisense… Expand
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Highly Cited
2007
Highly Cited
2007
Structure/Function Characterization of μ-Conotoxin KIIIA, an Analgesic, Nearly Irreversible Blocker of Mammalian Neuronal Sodium Channels*
Peptide neurotoxins from cone snails continue to supply compounds with therapeutic potential. Although several analgesic… Expand
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Highly Cited
2005
Highly Cited
2005
Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.
The voltage-gated Na(+) channels (Na(v)) form a family composed of 10 genes. The COOH termini of Na(v) contain a cluster of amino… Expand
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Highly Cited
2005
Highly Cited
2005
Electrophysiological properties of two axonal sodium channels, Nav1.2 and Nav1.6, expressed in mouse spinal sensory neurones.
Sodium channels Na(v)1.2 and Na(v)1.6 are both normally expressed along premyelinated and myelinated axons at different stages of… Expand
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Highly Cited
2004
Highly Cited
2004
Regulation of Neuronal Voltage-gated Sodium Channels by the Ubiquitin-Protein Ligases Nedd4 and Nedd4-2*
Nedd4 and Nedd4-2 are ubiquitin-protein ligases known to regulate a number of membrane proteins including receptors and ion… Expand
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Highly Cited
2004
Highly Cited
2004
A Nonsense Mutation of the Sodium Channel Gene SCN2A in a Patient with Intractable Epilepsy and Mental Decline
Mutations, exclusively missense, of voltage-gated sodium channel α subunit type 1 (SCN1A) and type 2 (SCN2A) genes were reported… Expand
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Highly Cited
2004
Highly Cited
2004
Benign familial neonatal-infantile seizures: characterization of a new sodium channelopathy.
We recently reported mutations in the sodium channel gene SCN2A in two families with benign familial neonatal-infantile seizures… Expand
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Highly Cited
2001
Highly Cited
2001
Compact Myelin Dictates the Differential Targeting of Two Sodium Channel Isoforms in the Same Axon
Voltage-dependent sodium channels are uniformly distributed along unmyelinated axons, but are highly concentrated at nodes of… Expand
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Highly Cited
2001
Highly Cited
2001
Differential Control of Clustering of the Sodium Channels Nav1.2 and Nav1.6 at Developing CNS Nodes of Ranvier
Na(v)1.6 is the main sodium channel isoform at adult nodes of Ranvier. Here, we show that Na(v)1.2 and its beta2 subunit, but not… Expand
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