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SB 258719

Known as: SB-258719 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity
&NA; The involvement of the 5‐HT7 receptor in nociception and pain, particularly chronic pain (i.e., neuropathic pain), has been… Expand
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Highly Cited
2010
Highly Cited
2010
Spinal 5-HT7 Receptors Play an Important Role in the Antinociceptive and Antihyperalgesic Effects of Tramadol and Its Metabolite, O-Desmethyltramadol, via Activation of Descending Serotonergic…
Background:Tramadol is an analgesic drug, and its mechanism of action is believed to be mediated by the &mgr;-opioid receptor. A… Expand
Highly Cited
2009
Highly Cited
2009
5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice
ABSTRACT This work aimed to evaluate the potential role of the 5‐HT7 receptor in nociception secondary to a sensitizing stimulus… Expand
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Highly Cited
2005
Highly Cited
2005
Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression
The affinity of several antidepressant and antipsychotic drugs for the 5-HT7 receptor and its CNS distribution suggest potential… Expand
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2004
2004
Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors.
Recombinant 5-hydroxytryptamine 5-HT7 receptors are known to express constitutive, i.e., agonist-independent activity… Expand
Highly Cited
2004
Highly Cited
2004
Selective 5-HT1A and 5-HT7 antagonists decrease epileptic activity in the WAG/Rij rat model of absence epilepsy
Recent studies have provided evidence that activation of 5-HT1A receptors increases epileptic activity in the WAG/Rij rat model… Expand
Highly Cited
2004
Highly Cited
2004
A 5-HT7 Heteroreceptor-Mediated Inhibition of [3H]Serotonin Release in Raphe Nuclei Slices of the Rat: Evidence for a Serotonergic–Glutamatergic Interaction
Midbrain slices containing the dorsal and medial raphe nuclei were prepared from rat brain, loaded with [3H]serotonin ([3H]5-HT… Expand
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Highly Cited
2003
Highly Cited
2003
The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor
The 5-HT(7) receptor is a recent addition to the 5-HT receptor family and to date there is no clear idea as to its potential role… Expand
Highly Cited
1999
Highly Cited
1999
5‐CT stimulation of adenylyl cyclase activity in guinea‐pig hippocampus: evidence for involvement of 5‐HT7 and 5‐HT1A receptors
A number of compounds, including the selective 5‐HT7 receptor antagonist SB‐258719, were investigated for their effect on [3H]‐5… Expand
Highly Cited
1998
Highly Cited
1998
Functional characterisation of the human cloned 5‐HT7 receptor (long form); antagonist profile of SB‐258719
1 The functional profile of the long form of the human cloned 5‐HT7 receptor (designated h5‐HT7(a)) was investigated using a… Expand
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