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SB 258719

Known as: SB-258719 
 
National Institutes of Health

Papers overview

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2016
2016
Contribution of serotonin and dopamine to changes in core body temperature and locomotor activity in rats following repeated administration of mephedrone.
The psychoactive effects of mephedrone are commonly compared with those of 3,4-methylenedioxymethamphetamine, but because of a… Expand
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2014
2014
Chronic resveratrol treatment exerts antihyperalgesic effect and corrects co-morbid depressive like behaviors in mice with mononeuropathy: Involvement of serotonergic system
Patients suffering from chronic neuropathic pain are at high risk of co-morbid depression, which burdens healthcare. This work… Expand
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2010
2010
Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity
The involvement of the 5-HT(7) receptor in nociception and pain, particularly chronic pain (i.e., neuropathic pain), has been… Expand
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2010
2010
Spinal 5-HT7 receptors play an important role in the antinociceptive and antihyperalgesic effects of tramadol and its metabolite, O-Desmethyltramadol, via activation of descending serotonergic…
BACKGROUND Tramadol is an analgesic drug, and its mechanism of action is believed to be mediated by the mu-opioid receptor. A… Expand
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Highly Cited
2009
Highly Cited
2009
5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice
This work aimed to evaluate the potential role of the 5-HT(7) receptor in nociception secondary to a sensitizing stimulus in mice… Expand
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Highly Cited
2005
Highly Cited
2005
Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression
The affinity of several antidepressant and antipsychotic drugs for the 5-HT7 receptor and its CNS distribution suggest potential… Expand
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2004
2004
Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors.
Recombinant 5-hydroxytryptamine 5-HT7 receptors are known to express constitutive, i.e., agonist-independent activity… Expand
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2004
2004
Selective 5-HT1A and 5-HT7 antagonists decrease epileptic activity in the WAG/Rij rat model of absence epilepsy
Recent studies have provided evidence that activation of 5-HT1A receptors increases epileptic activity in the WAG/Rij rat model… Expand
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2003
2003
The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor
The 5-HT(7) receptor is a recent addition to the 5-HT receptor family and to date there is no clear idea as to its potential role… Expand
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Highly Cited
1998
Highly Cited
1998
Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719.
1. The functional profile of the long form of the human cloned 5-HT7 receptor (designated h5-HT7(a)) was investigated using a… Expand
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