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SAR131675

 
National Institutes of Health

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Naphthyridines

Papers overview

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2019
2019
Inhibition of lymphatic proliferation by the selective VEGFR-3 inhibitor SAR131675 ameliorates diabetic nephropathy in db/db mice
Recent studies have demonstrated that chronic inflammation-induced lymphangiogenesis plays a crucial role in the progression of… Expand
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2019
2019
Identification of a unique resorcylic acid lactone derivative that targets both lymphangiogenesis and angiogenesis.
We synthesized 11 novel L-783277 derivatives, in which a structure rigidifying phenyl ring is incorporated into the 14-membered… Expand
2017
2017
Abstract 2634: EVT801: Standalone cancer immunotherapy in VEGFR3+ tumors and combination with immune checkpoint therapies in VEGFR3- tumors
In collaboration with Sanofi, we previously showed that inhibition of the VEGFR3 pathway by SAR131675 leads to reduction of tumor… Expand
2016
2016
Ginsenoside Rg1 enhances lymphatic transport of intrapulmonary silica via VEGF-C/VEGFR-3 signaling in silicotic rats.
Ginsenoside Rg1, extracted mainly from Panax ginseng, has been shown to exert strong pro-angiogenic activities in vivo. But it is… Expand
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2015
2015
Chronic inflammation, lymphangiogenesis, and effect of an anti‐VEGFR therapy in a mouse model and in human patients with aspiration pneumonia
Chronic inflammation induces lymphangiogenesis and blood vessel remodelling. Since aged pneumonia patients often have repeated… Expand
2015
2015
Ischemic tolerance is associated with VEGF-C and VEGFR-3 signaling in the mouse hippocampus
The functions of vascular endothelial growth factor C (VEGF-C) and the VEGF receptor 3 (VEGFR-3) in the nervous system are not… Expand
2014
2014
Specific Inhibition of the VEGFR-3 Tyrosine Kinase by SAR131675 Reduces Peripheral and Tumor Associated Immunosuppressive Myeloid Cells
Myeloid derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) represent prominent components in cancer… Expand
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2012
2012
SAR131675, a Potent and Selective VEGFR-3–TK Inhibitor with Antilymphangiogenic, Antitumoral, and Antimetastatic Activities
SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3… Expand
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2012
2012
Therapeutic Discovery SAR 131675 , a Potent and Selective VEGFR-3 – TK Inhibitor with Antilymphangiogenic , Antitumoral , and Antimetastatic Activities
SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3… Expand
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