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S3I 201

Known as: S3I-201, S3I201 
 
National Institutes of Health

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1 relation

Broader (1)

NSC 74859

Papers overview

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Highly Cited
2017
Highly Cited
2017
Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts
ABSTRACT During myocardial infarction, infiltrated macrophages have pivotal roles in cardiac remodeling and delayed M1 toward M2… Expand
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2016
2016
Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent
The Signal Transducer and Activator of Transcription 3 (STAT3) oncogene is a master regulator of many human cancers, and a well… Expand
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Highly Cited
2014
Highly Cited
2014
Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening
STAT3 regulates a variety of genes involved with cell proliferation, differentiation, apoptosis, angiogenesis, metastasis… Expand
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Highly Cited
2011
Highly Cited
2011
Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.
Autosomal dominant polycystic kidney disease (ADPKD) is a commonly inherited disorder mostly caused by mutations in PKD1… Expand
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Highly Cited
2010
Highly Cited
2010
A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy.
Accumulation of both interstitial myofibroblasts and excessive production of extracellular matrix proteins is a common pathway… Expand
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Highly Cited
2010
Highly Cited
2010
A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) signaling is frequently detected in cancer… Expand
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2010
2010
Inhibition of JAK/STAT signaling pathway prevents high-glucose-induced increase in endothelin-1 synthesis in human endothelial cells
Emerging evidence demonstrates the involvement of endothelin-1 (ET-1) in the pathophysiology of cardiovascular disorders… Expand
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Highly Cited
2009
Highly Cited
2009
Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.
Signal transducer and activator of transcription 3 (Stat3) protein is a cytosolic transcription factor that relays signals from… Expand
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Highly Cited
2007
Highly Cited
2007
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified from the National Cancer Institute… Expand
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Highly Cited
2007
Highly Cited
2007
An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects.
Stat3 is hyperactivated in many human tumors and represents a valid target for anticancer drug design. We present a novel small… Expand
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