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S-trans,trans-farnesylthiosalicylic acid

Known as: 2-(((2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl)sulfanyl)benzoic Acid, SALIRASIB 
A salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby… Expand
National Institutes of Health

Papers overview

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2015
2015
BACKGROUND Rat sarcoma (RAS)/rapidly accelerated fibrosarcoma (RAF)/mitogen-activated protein kinase activation (mutational or… Expand
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2013
2013
Ras activation is a frequent event in human hepatocarcinoma that may contribute to resistance towards apoptosis. Salirasib is a… Expand
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Highly Cited
2012
Highly Cited
2012
SummaryPurpose S-trans,trans-Farnesylthiosalicylic Acid (FTS, salirasib) inhibits Ras-dependent cell growth by dislodging all… Expand
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Highly Cited
2011
Highly Cited
2011
Introduction: KRAS mutations are present in 30% of lung adenocarcinomas. Salirasib prevents Ras membrane binding thereby blocking… Expand
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2009
2009
PurposeThis phase I first-in-human trial evaluated salirasib, an S-prenyl derivative of thiosalicylic acid that competitively… Expand
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Highly Cited
2009
Highly Cited
2009
Purpose: Despite recent progress, colon cancer is often resistant to combination chemotherapy, highlighting the need for… Expand
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Highly Cited
2008
Highly Cited
2008
Chronic activation of Ras proteins by mutational activation or by growth factor stimulation is a common occurrence in many human… Expand
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2007
2007
Aberrant Ras pathway functions contribute to the malignant phenotype of lung cancers. Inhibitors of Ras might therefore be… Expand
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Highly Cited
2007
Highly Cited
2007
BackgroundS-trans,trans-farnesylthiosalicylic acid (salirasib, FTS) is a synthetic small molecule that acts as a potent Ras… Expand
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2007
2007
Deregulation of Ras pathways results in complex abnormalities of multiple signaling cascades that contribute to human… Expand
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