S-trans,trans-farnesylthiosalicylic acid

Known as: 2-(((2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl)sulfanyl)benzoic Acid, Salirasib 
A salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2017
024619952017

Papers overview

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2015
2015
BACKGROUND Rat sarcoma (RAS)/rapidly accelerated fibrosarcoma (RAF)/mitogen-activated protein kinase activation (mutational or… (More)
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2012
2012
Purpose S-trans,trans-Farnesylthiosalicylic Acid (FTS, salirasib) inhibits Ras-dependent cell growth by dislodging all isoforms… (More)
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2012
2012
The small GTPase proteins, Ras and Rheb, serve as molecular switches regulating cell proliferation, differentiation and apoptosis… (More)
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2011
2011
INTRODUCTION KRAS mutations are present in 30% of lung adenocarcinomas. Salirasib prevents Ras membrane binding thereby blocking… (More)
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2009
2009
This phase I first-in-human trial evaluated salirasib, an S-prenyl derivative of thiosalicylic acid that competitively blocks RAS… (More)
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2008
2008
A liquid chromatography/tandem mass spectrometric (LC/MS/MS) assay was developed for the quantitative determination of salirasib… (More)
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2008
2008
Chronic activation of Ras proteins by mutational activation or by growth factor stimulation is a common occurrence in many human… (More)
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2007
2007
Deregulation of Ras pathways results in complex abnormalities of multiple signaling cascades that contribute to human… (More)
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2007
2007
Aberrant Ras pathway functions contribute to the malignant phenotype of lung cancers. Inhibitors of Ras might therefore be… (More)
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2002
2002
Ras transformation requires Ras membrane anchorage, which is promoted by a farnesylcysteine carboxymethyl ester and by additional… (More)
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