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S 23906

Known as: S-23906, S23906 
National Institutes of Health

Papers overview

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2013
2013
Protein recognition of the S23906-1-DNA adduct by nuclear proteins: direct involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
In a view to develop new DNA alkylating antitumour drugs, evaluating the precise mechanism of action and the molecular/cellular… 
2006
2006
Generation of replication-dependent double-strand breaks by the novel N2-G-alkylator S23906-1.
S23906-1, a new DNA alkylating agent that reacts with the exocyclic 2-NH2 group of guanine residues yielding monofunctional… 
2005
2005
Covalent binding of antitumor benzoacronycines to double-stranded DNA induces helix opening and the formation of single-stranded DNA: unique consequences of a novel DNA-bonding mechanism.
The majority of DNA-binding small molecules known thus far stabilize duplex DNA against heat denaturation. A high, drug-induced… 
2004
2004
A transesterification reaction is implicated in the covalent binding of benzo[b]acronycine anticancer agents with DNA and glutathion.
2003
2003
Covalent binding to glutathione of the DNA-alkylating antitumor agent, S23906-1.
The benzoacronycine derivative, S23906-1, was characterized recently as a novel potent antitumor agent through alkylation of the… 
2002
2002
Induction of apoptosis in HL-60 leukemia and B16 melanoma cells by the acronycine derivative S23906-1.
Review
2002
Review
2002
Acronycine derivatives as promising antitumor agents.
Originally isolated from an Australian plant, acronycine is an antitumor alkaloid with poor water solubility and low potency. The… 
2002
2002
Alkylation of guanine in DNA by S23906-1, a novel potent antitumor compound derived from the plant alkaloid acronycine.
The discovery of a new DNA-targeted antitumor agent is a challenging enterprise, and the elucidation of its mechanism of action… 
2002
2002
Sarcomelicope alkaloids as leads for the discovery of new antitumor acronycine derivatives
The acridone alkaloid acronycine first isolated from Acronychiabaueri Schott (Rutaceae) in 1948, was later shown to exhibit a… 
Highly Cited
2001
Highly Cited
2001
Induction of cyclin E and inhibition of DNA synthesis by the novel acronycine derivative S23906-1 precede the irreversible arrest of tumor cells in S phase leading to apoptosis.
S23906-1 is a diester derivative of 1,2-dihydrobenzo[b]acronycine with an unknown mechanism of action. This cytotoxic compound… 
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