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S 18327
Known as:
1-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)ethyl)-3-phenylimidazolin-2-one
, S-18327
, S18327
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (3)
Adrenergic alpha-1 Receptor Antagonists
Imidazoles
Isoxazoles
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Generalization of clozapine as compared to other antipsychotic agents to a discriminative stimulus elicited by the serotonin (5-HT)2A antagonist, MDL100,907
A. Dekeyne
,
L. Iob
,
M. Millan
Neuropharmacology
2003
Corpus ID: 43359832
2001
2001
Pharmacokinetic‐pharmacodynamic modelling in the early development phase of anti‐psychotics: a comparison of the effects of clozapine, S 16924 and S 18327 in the EEG model in rats
T. J. Parker
,
O. Della Pasqua
,
E. Loizillon
,
C. Chezaubernard
,
R. Jochemsen
,
M. Danhof
British journal of pharmacology
2001
Corpus ID: 10989024
The use of pharmacokinetic/pharmacodynamic (PK/PD) analysis in early compound development was investigated in the rat for two…
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2000
2000
S18327 (1-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperid-1-yl]ethyl}3-phenyl imidazolin-2-one), a Novel, Potential Antipsychotic Displaying Marked Antagonist Properties at α1- and α2-Adrenergic…
M. Millan
,
M. Brocco
,
+7 authors
A. Dekeyne
2000
Corpus ID: 97639727
S18327 was dose-dependently active in several models of potential antipsychotic activity involving dopaminergic hyperactivity…
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2000
2000
S18327 (1-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)piperid-1-yl]ethyl]3-phenyl imidazolin-2-one), a novel, potential antipsychotic displaying marked antagonist properties at alpha(1)- and alpha(2…
M. Millan
,
A. Gobert
,
+10 authors
J. Péglion
The Journal of pharmacology and experimental…
2000
Corpus ID: 40880908
S18327 displayed modest affinity for human (h)D(2) and hD(3) receptors and high affinity for hD(4) receptors. At each, S18327…
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2000
2000
S18327 (1-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)piperid-1-yl]ethyl]3-phenyl imidazolin-2-one), a novel, potential antipsychotic displaying marked antagonist properties at alpha(1)- and alpha(2…
M. Millan
,
M. Brocco
,
+7 authors
A. Dekeyne
The Journal of pharmacology and experimental…
2000
Corpus ID: 27516329
S18327 was dose-dependently active in several models of potential antipsychotic activity involving dopaminergic hyperactivity…
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