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S 1108

Known as: 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl)amino)-8-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, (6R-(6alpha,7beta(Z)))-, S-1108 
National Institutes of Health

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2 relations

Broader (2)

Cefcapene PivoxilCephalosporins

Papers overview

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1995
1995
[Pharmacokinetic and clinical studies of S-1108 in the pediatric field. Pediatric Study Group of S-1108].
S-1108 in granules, a new oral cephem antibiotic, was pharmacokinetically and clinically evaluated in the pediatric field and the… 
1994
1994
Synthesis and structure-activity relationships of 7 beta-[(Z)-2-(2- aminothiazol-4-yl)-3-(substituted)-2-propenoylamino]-3-cephems with C-3 substitutions.
Synthesis and biological activity of a series of 7 beta-[(Z)-2-(2- aminothiazol-4-yl)-3-(substituted)-2-propenoylamino]-3-cephe m… 
1993
1993
Carnitine status and safety after administration of S-1108, a new oral cephem, to patients
The metabolism and clinical safety of the pivalic acid-containing antibiotic S-1108, an orally active pro-drug cephalosporin… 
1993
1993
[Pharmacokinetic and clinical studies of S-1108 in the pediatric field].
Pharmacokinetic and clinical studies on S-1108, a new oral cephem antibiotic, were performed in the field pediatrics. The… 
1993
1993
[Clinical pharmacology and efficacy of S-1108].
We studied the pharmacokinetics of a new cephem antibiotic, S-1108, in patients with impaired kidney functions. Serum and urinary… 
1993
1993
[Influence of S-1108 on intestinal bacterial flora].
The effect of S-1108, a new oral cephem antibiotic, on intestinal bacterial flora was studied in tetra-contaminated mice and… 
1992
1992
Phase I clinical studies of S-1108: safety and pharmacokinetics in a multiple-administration study with special emphasis on the influence on carnitine body stores
S-1108, the prodrug of S-1006, was given to healthy volunteers three times a day (TID) for 8 days in a dose of 200 mg in a… 
1992
1992
Pharmacokinetic properties of new oral cephalosporins
1992
1992
Determination of pivaloylcarnitine in human plasma and urine by high-performance liquid chromatography with fluorescence detection.
A high-performance liquid chromatographic (HPLC) method was developed for the determination of pivaloylcarnitine, one of the… 
1992
1992
In vitro activity and susceptibility to hydrolysis of S-1006
The in vitro activity of S-1006, the active component of a new orally absorbed cephalosporin, S-1108, inhibited 90% of… 
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