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S-(3-hydroxypropyl)cysteine N-acetate

Known as: N-acetyl-S-(3-hydroxypropyl)cysteine, 3-Hydroxypropylmercapturic Acid, 1-(N-Acetylcysteinyl)-Propan-3-Ol 
A modified form of acetylcysteine that is a metabolite of acrolein and may be found in the urine of smokers.
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Acetylcysteine
analogs & derivativeshydroxypropyl methacrylate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review.
Review
2012
Review
2012
Polymeric conjugates for drug delivery.
The field of polymer therapeutics has evolved over the past decade and has resulted in the development of polymer-drug conjugates… 
Review
2010
Review
2010
HPMA copolymers: origins, early developments, present, and future.
Highly Cited
2009
Highly Cited
2009
Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer.
Phase I studies of [N-(2-hydroxypropyl)methacrylamide] (HPMA) copolymer-doxorubicin previously showed signs of activity coupled… 
Highly Cited
2004
Highly Cited
2004
Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470
Angiogenesis is crucial for tumor growth. Angiogenesis inhibitors, such as O-(chloracetyl-carbamoyl) fumagillol (TNP-470), are… 
Review
2002
Review
2002
Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer.
Measurement of human urinary carcinogen metabolites is a practical approach for obtaining important information about tobacco and… 
Highly Cited
2001
Highly Cited
2001
New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties.
Review
2000
Review
2000
HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action.
Highly Cited
1995
Highly Cited
1995
Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier.
Highly Cited
1987
Highly Cited
1987
Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats.
A copolymer of N-(2-hydroxypropyl) methacrylamide (HPMA) and N-methacryloyltyrosinamide was prepared and fractionated using… 
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