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Roller Bottle

Bottles utilized as vessels for intermediate scale preparations of attachment-dependent cultured cells. Denoted 'roller bottles' because they are… 
National Institutes of Health

Papers overview

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2013
2013
AUGMENTATION OF BIOLOGICAL TITER OF FOOT AND MOUTH DISEASE VIRUS IN IN VITRO CULTURE
8.34 ± 0.07 units of virus TCID50 on 0.2 g of micro-carriers suspending in 200 ml of the growth medium in stirring bottle. The… 
2009
2009
Determinant factors for hybridmyeloma culture (H9r9) in the yield of anti - D – impact of medium (IMDM and RPMI), serum (FCS) and cell density
The hybridoma (H9r9) were cultured in roller bottles with two media viz IMDM and RPMI with FCS (3% & 5%). The parameters such as… 
2002
2002
Enhanced Mixing and Mass Transfer in a Recirculation Loop Results in High Cell Densities in a Roller Bottle Reactor
A recirculation loop added to a large‐scale roller bottle reactor resulted in high cell densities as compared to standard roller… 
1999
1999
Computational and experimental investigation of flow and particle settling in a roller bottle bioreactor.
It is shown that cell settling is a key factor affecting the performance of roller bottle bioreactors. The two-dimensional cross… 
1999
1999
Membrane-based cell culture systems--an alternative to in vivo production of monoclonal antibodies.
A new generation of membrane-based cell culture devices especially designed for small scale production of monoclonal antibodies… 
1997
1997
Production of rhEPO with a serum-free medium in the packed bed bioreactor.
Recombinant CHO (C2) cells producing human erythropoietin (rhEPO) were cultured with DMEM:F12 media containing 5% FBS for 8-10… 
1992
1992
Optimization of a Roller Bottle Process for the Production of Recombinant Erythropoietin
Erythropoietin (EPO) is a glycoprotein hormone that regulates red blood cell production by controlling both the proliferation and… 
1991
1991
Distribution of 3H in rat conceptus cultured in vitro following brief administration of [3H]thymidine.
Rat embryos with intact visceral yolk sacs, explanted at 12 1/2 days of gestation, were cultured in vitro for up to 60 min in… 
1985
1985
Production of herpes simplex virus from MRC-5 cells grown in a glass bead culture system.
The failure of microcarrier systems to provide significant quantities of infectious Herpes simplex virus (HSV) for vaccine… 
1982
1982
Large‐scale preparation and characterization of human colony‐stimulating factor
In order to obtain human granulocytic colony‐stimulating factor (G‐CSF) in large quantities, a large‐scale culture system of… 
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