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Ribose-Phosphate Pyrophosphokinase

Known as: Ribosephosphate Pyrophosphokinase, PRPP Synthetase, ATP:ribose-5-phosphate pyrophosphotransferase 
An enzyme that catalyzes the formation of phosphoribosyl pyrophosphate from ATP and ribose-5-phosphate. EC 2.7.6.1.
National Institutes of Health

Related topics

Related topics

12 relations
In BloodPRPS1 geneProcess of secretionantagonists & inhibitors

Narrower (4)

PRPS1 protein, humanPRPS2 protein, mousePhosphoribosylpyrophosphate Synthetase SuperactivityPhosphoribosylpyrophosphate synthetase deficiency

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1989
1989
Rat liver phosphoribosyl pyrophosphate synthetase: existence of the purified enzyme as heterogeneous aggregates and identification of the catalytic subunit.
Mammalian phosphoribosyl pyrophosphate (PRPP) synthetase has been extensively investigated. However, considerable ambiguity… 
Highly Cited
1986
Highly Cited
1986
Protection against cis-diamminedichloroplatinum cytotoxicity and mutagenicity in V79 cells by 2-[(aminopropyl)amino]ethanethiol.
The effect(s) of the radioprotector 2-[(aminopropyl)amino]ethanethiol (WR1065) on cis-diamminedichloroplatinum(II) (cis-DDP… 
Highly Cited
1974
Highly Cited
1974
Purification and properties of phosphoribosyl pyrophosphate synthetase from rat liver.
Highly Cited
1974
Highly Cited
1974
The effect of cyclic nucleotides on purine biosynthesis and the induction of PRPP synthetase during lymphocyte activation.
1974
1974
Stability and regulation of phosphoribosyl pyrophosphate synthetase from rat liver.
1974
1974
Hypouricemic, mentally retarded infant with a defect of 5-phosphoribosyl-1-pyrophosphate synthetase of erythrocytes.
WADA, Y., NISHIMURA, Y., TANABU, M., YOSHIMURA, Y., IINUMA, K., YosHIDA, T. and ARAKAWA, Ts. Hypouricemic, Mentally Retarded… 
1974
1974
A direct, stimulating effect of cyclic GMP on purified phosphoribosyl pyrophosphate synthetase and its antagonism by cyclic AMP.
1973
1973
Nonspherocytic Haemolytic Anaemia with Increased Red Cell Adenine Nucleotides, Glutathione and Basophilic Stippling and Ribosephosphate Pyrophosphokinase (RPK) Deficiency: Studies on Two New Kindreds
The second and third kindreds with hereditary haemolytic anaemia characterized by marked basophilic stippling of the erythrocytes… 
Highly Cited
1972
Highly Cited
1972
Studies on human erythrocyte nucleotide metabolism. II. Nonspherocytic hemolytic anemia, high red cell ATP, and ribosephosphate pyrophosphokinase (RPK, E.C.2.7.6.1) deficiency.
A 29-yr-old black woman was found to have a long-standing, nonspherocytic hemolytic disorder associated with a marked reduction… 
Highly Cited
1969
Highly Cited
1969
Regulation of the synthesis of 5-phosphoribosyl-I-pyrophosphate in intact red blood cells and in cell-free preparations.
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