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As the current efficacy of oncolytic viruses (OVs) as monotherapy is limited, exploration of OVs as part of a broader… Expand Multiple myeloma remains incurable and the majority of patients die within 5 years of diagnosis. Reolysin, the infusible form of… Expand Oncolytic virotherapy with reovirus has demonstrated anti-cancer activity and minimal toxicity in clinical trials, but the… Expand ABSTRACT Mammalian orthoreoviruses induce apoptosis in vivo and in vitro; however, the specific mechanism by which apoptosis is… Expand Reoviruses induce apoptosis both in cultured cells and in vivo. Apoptosis plays a major role in the pathogenesis of reovirus… Expand Virus-induced activation of nuclear factor-kappa B (NF-κB) is required for Type 3 (T3) reovirus-induced apoptosis. We now show… Expand Reovirus-induced murine myocarditis provides an excellent model for the human disease. Previously, we showed that reovirus… Expand TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis in susceptible cells by binding to death receptors 4 (DR4) and 5… Expand ABSTRACT Reovirus-induced acute myocarditis in mice serves as a model to investigate non-immune-mediated mechanisms of viral… Expand The translational apparatus in cell-free extracts prepared from L cells infected with reovirus undergoes a time-dependent… Expand