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Objective To investigate the mechanism of tissue uptake of renin. Design Angiotensin peptide formation in tissues is dependent on… Expand Renin is a key enzyme in the renin-angiotensin system (RAS) which controls the blood pressure and electrolyte balance. By… Expand We have isolated the renin gene from a Sprague-Dawley rat genomic library and determined its complete nucleotide sequence. The… Expand Renin (EC 126.96.36.199) is an aspartyl protease that cleaves its only known substrate, angiotensinogen, to release the vasopressor… Expand The Ren-1 locus of mice encodes the protease renin, which with converting enzyme processes angiotensinogen to the potent… Expand A model has been constructed using computer graphics for human renin based on the sequence derived from that of the gene and the… Expand The primary structure of human renin precursor has been deduced from its cDNA sequence. A library of cDNA clones was constructed… Expand With the objective of clarifying the nature of renin-like activity in the brain, we have devised methods to distinguish true… Expand Enzymes, similar to kidney renin, are present in extrarenal tissue of most mammals; they hydrolyze angiotensinogen to form… Expand Two interconvertible renins were isolated from extracts of the pig renal cortex at neutral pH and shown to be protein-bound… Expand