Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta

Known as: Recombinant VSV-IFN-beta, VSV-hIFN-b 
A recombinant, replicating oncolytic vesicular stomatitis virus (VSV) carrying the human interferon-beta (IFN-b) gene, with potential… (More)
National Institutes of Health

Papers overview

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2015
2015
Lassa-vesicular stomatitis chimeric virus safely destroys brain tumors.
UNLABELLED High-grade tumors in the brain are among the deadliest of cancers. Here, we took a promising oncolytic virus… (More)
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2012
2012
Potent systemic therapy of Multiple Myeloma utilizing Oncolytic Vesicular stomatitis virus coding for Interferon-beta
Multiple myeloma (MM) is an incurable malignancy of plasma secreting B cells disseminated in the bone marrow. Successful… (More)
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2010
2010
Generation of VSV pseudotypes using recombinant ΔG-VSV for studies on virus entry, identification of entry inhibitors, and immune responses to vaccines.
Vesicular stomatitis virus (VSV) is a prototypic enveloped animal virus that has been used extensively to study virus entry… (More)
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2009
2009
Vesicular stomatitis virus as a novel cancer vaccine vector to prime antitumor immunity amenable to rapid boosting with adenovirus.
Vesicular stomatitis virus (VSV) has proven to be an effective vaccine vector for immunization against viral infection, but its… (More)
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2007
2007
Peripheral, but not central nervous system, type I interferon expression in mice in response to intranasal vesicular stomatitis virus infection
Type I interferon (IFN) is critical for resistance of mice to infection with vesicular stomatitis virus (VSV). Wild type (wt) VSV… (More)
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2007
2007
Variable deficiencies in the interferon response enhance susceptibility to vesicular stomatitis virus oncolytic actions in glioblastoma cells but not in normal human glial cells.
With little improvement in the poor prognosis for humans with high-grade glioma brain tumors, alternative therapeutic strategies… (More)
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Highly Cited
2006
Highly Cited
2006
Visualization of intracellular transport of vesicular stomatitis virus nucleocapsids in living cells.
The phosphoprotein (P) of vesicular stomatitis virus (VSV) is a subunit of the viral RNA polymerase. In previous studies, we… (More)
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Highly Cited
2003
Highly Cited
2003
Development of recombinant vesicular stomatitis viruses that exploit defects in host defense to augment specific oncolytic activity.
Vesicular stomatitis virus (VSV) is a negative-stranded RNA virus normally sensitive to the antiviral actions of alpha/beta… (More)
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2003
2003
Foamy virus envelope glycoprotein-mediated entry involves a pH-dependent fusion process.
In general, enveloped viruses use two different entry strategies and are classified accordingly into pH-dependent and pH… (More)
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2002
2002
Characterization of vesicular stomatitis virus recombinants that express and incorporate high levels of hepatitis C virus glycoproteins.
We generated recombinant vesicular stomatitis viruses (VSV) expressing genes encoding hybrid proteins consisting of the… (More)
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