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Recombinant Prothymosin Alpha

Known as: Prothymosin Alpha 
A recombinant form of the endogenous polypeptide hormone that exerts immunomodulatory effects primarily on mononuclear cells. Prothymosin alpha… Expand
National Institutes of Health

Related topics

Related topics

3 relations
PTMA genePTMA protein, humanprothymosin alpha

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
ProT-α gene transfer attenuates cardiopulmonary remedying and mortality in a flow-induced pulmonary hypertension rat model.
BACKGROUND ProT is a cell survival gene, which modulates oxidative stress and transforming growth factor (TGF)-β signaling. We… Expand
2017
2017
57PIn vivo study of the vaccine adjuvants prothymosin alpha and prothymosin alpha(100-109) in melanoma
 
2015
2015
Prothymosin α variants isolated from CD8+ T cells and cervicovaginal fluid suppress HIV-1 replication through type I interferon induction.
Soluble factors from CD8(+) T cells and cervicovaginal mucosa of women are recognized as important in controlling human… Expand
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2014
2014
Immune responses induced by the TLR-4 agonist-based adjuvant prothymosin alpha.
11131 Background: The immunomodulator prothymosin α (proTα) stimulates immune subpopulations via generating an optimized cytokine… Expand
2013
2013
Generation of Mature Nα-Terminal Acetylated Thymosin α1 by Cleavage of Recombinant Prothymosin α
Nα-terminal acetylation of peptides plays an important biological role but is rarely observed in prokaryotes. Nα-terminal… Expand
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2005
2005
The immunologically active site of prothymosin α is located at the carboxy-terminus of the polypeptide. Evaluation of its in vitro effects in cancer patients
Prothymosin α (proTα) is a 109 amino acid long polypeptide presenting distinct immunoenhancing activity in vitro and in vivo… Expand
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2002
2002
Study on the biological activity of recombinant human prothymosin α in vitro
OBJECTIVE To study on the biological activity of human prothymosin α(ProTα) in vitro.METHODS The effects of ProTα on the E… Expand
2001
2001
Prothymosin alpha enhances protective immune responses induced by oral DNA vaccination against pseudorabies delivered by Salmonella choleraesuis.
Previously, we showed that vaccination with the glycoprotein D (gD) gene of pseudorabies virus (PrV) delivered by Escherichia… Expand
1999
1999
Increased generation of autologous tumor-reactive lymphocytes by anti-CD3 monoclonal antibody and prothymosin α
Abstract Anti-CD3 monoclonal antibody (mAb) activates in vitro peripheral blood mononuclear cells (PBMC) to lyse a variety of… Expand
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1998
1998
Prothymosin α Stimulates Ca2+-dependent Phosphorylation of Elongation Factor 2 in Cellular Extracts*
Prothymosin α (PTA) stimulates in a dose-dependent manner the phosphorylation of a 105-kDa protein (p105) in cell extracts from… Expand
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