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Recombinant Prothymosin Alpha

Known as: Prothymosin Alpha 
A recombinant form of the endogenous polypeptide hormone that exerts immunomodulatory effects primarily on mononuclear cells. Prothymosin alpha… Expand
National Institutes of Health

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3 relations
PTMA genePTMA protein, humanprothymosin alpha

Papers overview

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2017
2017
57PIn vivo study of the vaccine adjuvants prothymosin alpha and prothymosin alpha(100-109) in melanoma
 
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2015
2015
Prothymosin α variants isolated from CD8+ T cells and cervicovaginal fluid suppress HIV-1 replication through type I interferon induction.
Soluble factors from CD8(+) T cells and cervicovaginal mucosa of women are recognized as important in controlling human… Expand
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2014
2014
Immune responses induced by the TLR-4 agonist-based adjuvant prothymosin alpha.
11131 Background: The immunomodulator prothymosin α (proTα) stimulates immune subpopulations via generating an optimized cytokine… Expand
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2013
2013
Generation of Mature Nα-Terminal Acetylated Thymosin α1 by Cleavage of Recombinant Prothymosin α
Nα-terminal acetylation of peptides plays an important biological role but is rarely observed in prokaryotes. Nα-terminal… Expand
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2005
2005
The immunologically active site of prothymosin α is located at the carboxy-terminus of the polypeptide. Evaluation of its in vitro effects in cancer patients
Prothymosin α (proTα) is a 109 amino acid long polypeptide presenting distinct immunoenhancing activity in vitro and in vivo… Expand
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2002
2002
Study on the biological activity of recombinant human prothymosin α in vitro
OBJECTIVE To study on the biological activity of human prothymosin α(ProTα) in vitro.METHODS The effects of ProTα on the E… Expand
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2001
2001
Prothymosin alpha enhances protective immune responses induced by oral DNA vaccination against pseudorabies delivered by Salmonella choleraesuis.
Previously, we showed that vaccination with the glycoprotein D (gD) gene of pseudorabies virus (PrV) delivered by Escherichia… Expand
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1999
1999
Increased generation of autologous tumor-reactive lymphocytes by anti-CD3 monoclonal antibody and prothymosin α
Abstract Anti-CD3 monoclonal antibody (mAb) activates in vitro peripheral blood mononuclear cells (PBMC) to lyse a variety of… Expand
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1998
1998
Prothymosin alpha stimulates Ca2+-dependent phosphorylation of elongation factor 2 in cellular extracts.
Prothymosin alpha (PTA) stimulates in a dose-dependent manner the phosphorylation of a 105-kDa protein (p105) in cell extracts… Expand
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1997
1997
Recombinant human prothymosin alpha influences on immunity and behaviour
 
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