Recombinant Interleukin-2

Known as: T-Cell Growth Factor, TSF, IL-2 
One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-2 is made by a type of T… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
BACKGROUND Dysfunction of regulatory T (Treg) cells has been detected in diverse inflammatory disorders, including chronic graft… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Preclinical and preliminary clinical data indicate that ch14.18, a monoclonal antibody against the tumor-associated… (More)
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Highly Cited
2006
Highly Cited
2006
Although interleukin-2 (IL-2) was initially characterized as the primary T-cell growth factor following in vitro activation, less… (More)
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Highly Cited
1995
Highly Cited
1995
PURPOSE To determine the efficacy and toxicity of a high-dose interleukin-2 (IL-2) regimen in patients with metastatic renal cell… (More)
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Highly Cited
1993
Highly Cited
1993
Mice deficient for interleukin-2 develop normally during the first 3-4 weeks of age. However, later on they become severely… (More)
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Highly Cited
1991
Highly Cited
1991
Antigen receptor stimulation of mature alpha beta T lymphocytes can lead either to proliferation or death. Programmed cell death… (More)
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Highly Cited
1988
Highly Cited
1988
Lymphocytes extracted from freshly resected melanomas can be expanded in vitro and can often mediate specific lysis of autologous… (More)
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Highly Cited
1987
Highly Cited
1987
We studied the effects of adoptive immunotherapy with lymphokine-activated killer (LAK) cells plus interleukin-2 or therapy with… (More)
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Highly Cited
1987
Highly Cited
1987
Adoptive immunotherapy involving bolus-dose recombinant interleukin-2 (rIL-2) has been reported to induce tumor regression in… (More)
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Highly Cited
1985
Highly Cited
1985
We describe here the preliminary results of the systemic administration of autologous lymphokine-activated killer (LAK) cells and… (More)
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