Recombinant Human Interleukin-21

Known as: Denenicokin, IL-21, rIL-21 
A recombinant peptide similar to or identical to endogenous human cytokine interleukin-21 (IL-21) with potential antineoplastic activity. Denenicokin… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
IL-10 is believed to underlie many of the immunologic defects in human visceral leishmaniasis (VL). We have identified CD4(+)CD25… (More)
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Highly Cited
2010
Highly Cited
2010
Deregulated production of IL-17 and IL-21 plays a key pathogenic role in many autoimmune disorders. A delineation of the… (More)
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Highly Cited
2009
Highly Cited
2009
Interleukin (IL) 6 is a proinflammtory cytokine produced by antigen-presenting cells and nonhematopoietic cells in response to… (More)
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Highly Cited
2009
Highly Cited
2009
Phase II clinical trials revealed that the lymphocyte-depleting humanized monoclonal antibody alemtuzumab (Campath-1H) is highly… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE Human interleukin-21 (IL-21) is a class I cytokine that mediates activation of CD8(+) T cells, natural killer (NK) cells… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE A phase I study of patients with metastatic malignant melanoma (MM) and renal cell carcinoma (RCC) evaluated the safety… (More)
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Review
2008
Review
2008
T helper 17 (Th17) cells belong to a recently identified T helper subset, in addition to the traditional Th1 and Th2 subsets… (More)
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Highly Cited
2008
Highly Cited
2008
IL-21 is a pleiotropic type I cytokine that shares the common cytokine receptor gamma chain and plays important roles for normal… (More)
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2006
2006
IL-21 is an IL-2-like cytokine, signaling through a specific IL-21R and the IL-2R gamma-chain. Because the TS/A mammary… (More)
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Highly Cited
2004
Highly Cited
2004
IL-21 is a cytokine that regulates the activation of T and NK cells and promotes the proliferation of B cells activated via CD40… (More)
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