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Recombinant Human Interleukin-21

Known as: Denenicokin, IL-21, rIL-21 
A recombinant peptide similar to or identical to endogenous human cytokine interleukin-21 (IL-21) with potential antineoplastic activity. Denenicokin… 
National Institutes of Health

Related topics

Related topics

12 relations
B-LymphocytesDendritic CellsIL17C geneIL21 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
IL-21 and IRF4: A Complex Partnership in Immune and Metabolic Regulation
Adipose tissue is comprised of a community of different immune cells that contributes to regulation of energy storage and release… 
2013
2013
Interleukin-21 Receptor Signalling Is Important for Innate Immune Protection against HSV-2 Infections
Interleukin (IL) -21 is produced by Natural Killer T (NKT) cells and CD4+ T cells and is produced in response to virus infections… 
2013
2013
Phase I dose escalation study of recombinant interleukin-21 (rIL-21; BMS-982470) in combination with nivolumab (anti-PD-1; BMS-936558; ONO-4538) in patients (pts) with advanced or metastatic solid…
TPS3112 Background: Programmed death-1 (PD-1) is an immune checkpoint receptor that attenuates T-cell activation by binding to… 
2012
2012
IL-21R EXPRESSION ON CD8+T CELLS PROMOTES CD8+T CELL ACTIVATION IN COXSACKIEVIRUS B3 INDUCED MYOCARDITIS
Objectives To evaluate the role of IL-21 in promoting CD8 T cell mediated cardiac injury in myocarditis. Methods To evaluate the… 
Review
2011
Review
2011
Interleukin-21 as a potential therapeutic target for systemic lupus erythematosus
Interleukin-21(IL-21) is the most recently discovered member of the type-I cytokine family. Structurally, IL-21 shows homology to… 
Review
2011
Review
2011
Targeting interleukin-21 in inflammatory diseases
Introduction: IL-21, a new member of the type 1 cytokine superfamily, is produced by various subsets of CD4+ T cells and binds to… 
Review
2010
Review
2010
Novel Gamma-Chain Cytokines as Candidate Immune Modulators in Immune Therapies for Cancer
Cytokines that signal through the common-gamma chain are potent growth factors for T cells and natural killer cells. Interleukin… 
2008
2008
Activity of recombinant human interleukin-21 (rIL-21) in patients (pts) with stage IV malignant melanoma (MM) without prior treatment: Clinical data from a phase IIa study
3042 Background: IL-21 has a key role in cancer immunology. We have previously described a phase 1 study of rIL-21 in pts with… 
2008
2008
Recombinant IL-21 (rIL-21) in combination with sorafenib: Interim results from a phase 1/2 study in patients with metastatic renal cell cancer (mRCC)
16008 Background: Despite the impact of tyrosine kinase inhibitors on the outcome for mRCC, complete responses are rare and long… 
2007
2007
[Serum IL-21 level in patients with primary Sjogren's syndrome and clinical significance of IL-21].
AIM To investigate the relation between the change of serum IL-21 level and other laboratory indexes by detecting serum IL-21… 
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