FAQ

Recombinant Fractalkine

Known as: CX3CL1, Fractalkine, Neurotactin 
A pro-inflammatory delta chemokine with potential antineoplastic activity. Fractalkine induces the adhesion and migration of T lymphocytes, monocytes… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2018
0102019982018

Related topics

Related topics

3 relations
CX3CL1 geneCX3CL1 protein, humanFractalkine

Related mentions per year

Related mentions per year

1985-2018
19801990200020102020
Recombinant Fractalkine
CX3CL1 gene
Fractalkine
CX3CL1 protein, human

Papers overview

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Highly Cited
2011
Highly Cited
2011
CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity.
The protective/neurotoxic role of fractalkine (CX3CL1) and its receptor CX3C chemokine receptor 1 (CX3CR1) signaling in… (More)
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Highly Cited
2008
Highly Cited
2008
Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis.
BACKGROUND Monocyte-derived foam cells are the hallmark of early atherosclerosis, and recent evidence indicates that chemokines… (More)
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Highly Cited
2007
Highly Cited
2007
Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension.
Pulmonary hypertension is characterised by a progressive increase in pulmonary arterial resistance due to endothelial and smooth… (More)
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Highly Cited
2004
Highly Cited
2004
A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.
The present experiments examined the role of spinal proinflammatory cytokines [interleukin-1beta (IL-1)] and chemokines… (More)
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Highly Cited
2002
Highly Cited
2002
Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury.
Fractalkine (FKN), also known as neurotactin, is a CX(3)C chemokine that exists in both secreted and neuronal membrane-bound… (More)
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Highly Cited
2001
Highly Cited
2001
Expression of respiratory syncytial virus-induced chemokine gene networks in lower airway epithelial cells revealed by cDNA microarrays.
The Paramyxovirus respiratory syncytial virus (RSV) is the primary etiologic agent of serious epidemic lower respiratory tract… (More)
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Highly Cited
2001
Highly Cited
2001
Fractalkine, a novel chemokine in rheumatoid arthritis and in rat adjuvant-induced arthritis.
OBJECTIVE To examine the expression of the novel CX3C chemokine fractalkine (Fkn) and its receptor (CX3CR1) in rheumatoid… (More)
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Highly Cited
2000
Highly Cited
2000
Fractalkine-mediated endothelial cell injury by NK cells.
Endothelial cells (ECs) are primary targets of immunological attack, and their injury can lead to vasculopathy and organ… (More)
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Highly Cited
2000
Highly Cited
2000
Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation.
Among the chemokine family, fractalkine shows unusual properties: it exists as a membrane-bound and soluble protein, and both… (More)
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Highly Cited
1998
Highly Cited
1998
Fractalkine and CX3CR1 Mediate a Novel Mechanism of Leukocyte Capture, Firm Adhesion, and Activation under Physiologic Flow
Leukocyte migration into sites of inflammation involves multiple molecular interactions between leukocytes and vascular… (More)
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