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Receptors, Notch

Known as: Notch Receptors, DSL Protein, Notch Proteins 
A family of transmembrane receptors with multiple extracellular EGF repeats and a DSL (notch) domain. These proteins interact with their cell-bound… 
National Institutes of Health

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Related topics

9 relations
Embryonic DevelopmentIn BloodIntercellular Communication Processagonists

Narrower (2)

NOTCH4 protein, humanNotch4 protein, mouse

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Comprehensive genomic profiles of small cell lung cancer
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the… 
Highly Cited
2011
Highly Cited
2011
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma
Squamous cell carcinomas (SCCs) are one of the most frequent forms of human malignancy, but, other than TP53 mutations, few… 
Highly Cited
2010
Highly Cited
2010
Therapeutic antibody targeting of individual Notch receptors
The four receptors of the Notch family are widely expressed transmembrane proteins that function as key conduits through which… 
Review
2007
Review
2007
Regulation of vascular morphogenesis by Notch signaling.
The Notch pathway is a versatile regulator of cell fate specification, growth, differentiation, and patterning processes in… 
Review
2006
Review
2006
Recent insights into the role of Notch signaling in tumorigenesis.
Members of the Notch family of transmembrane receptors play an important role in cell fate determination. Over the past decade, a… 
Highly Cited
2002
Highly Cited
2002
Identification of a Family of Mastermind-Like Transcriptional Coactivators for Mammalian Notch Receptors
ABSTRACT The molecular mechanisms by which Notch receptors induce diverse biological responses are not fully understood. We… 
Highly Cited
2000
Highly Cited
2000
MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors
Notch receptors are involved in cell-fate determination in organisms as diverse as flies, frogs and humans. In Drosophila… 
Highly Cited
2000
Highly Cited
2000
Notch signaling is essential for vascular morphogenesis in mice.
The Notch gene family encodes large transmembrane receptors that are components of an evolutionarily conserved intercellular… 
Highly Cited
2000
Highly Cited
2000
Calcium Depletion Dissociates and Activates Heterodimeric Notch Receptors
ABSTRACT Notch receptors participate in a highly conserved signaling pathway that regulates morphogenesis in multicellular… 
Highly Cited
1997
Highly Cited
1997
Kuzbanian Controls Proteolytic Processing of Notch and Mediates Lateral Inhibition during Drosophila and Vertebrate Neurogenesis
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