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Ras Protein Specific Guanine Nucleotide Releasing Factor 1

Known as: ras Guanine Nucleotide Releasing Factor, GNRP, CDC25 
The protein is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has… 
National Institutes of Health

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CDC25 and CHK1 Regulatory PathwayG2-M Cell Cycle CheckpointIn BloodMemory
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CDC25 protein, S cerevisiae

Papers overview

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Review
2006
Review
2006
The when and wheres of CDC25 phosphatases.
Highly Cited
2003
Highly Cited
2003
The NMDA Receptor Is Coupled to the ERK Pathway by a Direct Interaction between NR2B and RasGRF1
Highly Cited
2001
Highly Cited
2001
Pin1 acts catalytically to promote a conformational change in Cdc25.
Highly Cited
2000
Highly Cited
2000
The Chk1 Protein Kinase and the Cdc25C Regulatory Pathways Are Targets of the Anticancer Agent UCN-01*
A checkpoint operating in the G2 phase of the cell cycle prevents entry into mitosis in the presence of DNA damage. UCN-01, a… 
Highly Cited
1998
Highly Cited
1998
The mitotic peptidyl‐prolyl isomerase, Pin1, interacts with Cdc25 and Plx1
The cis/trans peptidyl‐prolyl isomerase, Pin1, is a regulator of mitosis that is well conserved from yeast to man. Here we… 
Highly Cited
1996
Highly Cited
1996
Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts
Cdc2, the cyclin-dependent kinase that controls mitosis, is negatively regulated by phosphorylation on its threonine-14 and… 
Highly Cited
1996
Highly Cited
1996
Identification of Grf1 on mouse chromosome 9 as an imprinted gene by RLGS–M
Normal mammalian development requires a diploid combination of both haploid parental genomes1. Uniparental disomy for certain… 
Highly Cited
1993
Highly Cited
1993
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
A human complementary DNA was isolated that encodes a widely expressed protein, hSos1, that is closely related to Sos, the… 
Highly Cited
1993
Highly Cited
1993
Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos.
To contribute to a deeper understanding of M-phase control in eukaryotic cells, we have constructed a model based on the… 
Highly Cited
1987
Highly Cited
1987
The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway
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