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Ras Protein Specific Guanine Nucleotide Releasing Factor 1

Known as: ras Guanine Nucleotide Releasing Factor, GNRP, CDC25 
The protein is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has… Expand
National Institutes of Health

Papers overview

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Review
2006
Review
2006
The CDC25 phosphatases are key regulators of normal cell division and the cell's response to DNA damage. Earlier studies… Expand
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Highly Cited
2005
Highly Cited
2005
The Cdc25 family of protein phosphatases positively regulates cell division by activating cyclin-dependent protein kinases (CDKs… Expand
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Highly Cited
2003
Highly Cited
2003
It has been known for over a decade that inhibition of protein phosphatase 1 (PP1) activity prevents entry into M phase, but the… Expand
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Highly Cited
2001
Highly Cited
2001
Pin1 is an essential protein that can peptidyl-prolyl-isomerize small phosphopeptides. It has been suggested that Pin1 regulates… Expand
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Highly Cited
2000
Highly Cited
2000
A checkpoint operating in the G(2) phase of the cell cycle prevents entry into mitosis in the presence of DNA damage. UCN-01, a… Expand
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Highly Cited
1998
Highly Cited
1998
The cis/trans peptidyl-prolyl isomerase, Pin1, is a regulator of mitosis that is well conserved from yeast to man. Here we… Expand
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Highly Cited
1996
Highly Cited
1996
Cdc2, the cyclin-dependent kinase that controls mitosis, is negatively regulated by phosphorylation on its threonine-14 and… Expand
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Highly Cited
1996
Highly Cited
1996
Normal mammalian development requires a diploid combination of both haploid parental genomes1. Uniparental disomy for certain… Expand
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Highly Cited
1993
Highly Cited
1993
A human complementary DNA was isolated that encodes a widely expressed protein, hSos1, that is closely related to Sos, the… Expand
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Highly Cited
1993
Highly Cited
1993
To contribute to a deeper understanding of M-phase control in eukaryotic cells, we have constructed a model based on the… Expand
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