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Ras Protein Specific Guanine Nucleotide Releasing Factor 1

Known as: ras Guanine Nucleotide Releasing Factor, GNRP, CDC25 
The protein is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has… Expand
National Institutes of Health

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CDC25 and CHK1 Regulatory PathwayG2-M Cell Cycle CheckpointIn BloodMemory
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CDC25 protein, S cerevisiae

Papers overview

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Review
2006
Review
2006
The when and wheres of CDC25 phosphatases.
The CDC25 phosphatases are key regulators of normal cell division and the cell's response to DNA damage. Earlier studies… Expand
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Highly Cited
2005
Highly Cited
2005
Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases.
The Cdc25 family of protein phosphatases positively regulates cell division by activating cyclin-dependent protein kinases (CDKs… Expand
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Highly Cited
2003
Highly Cited
2003
PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation.
It has been known for over a decade that inhibition of protein phosphatase 1 (PP1) activity prevents entry into M phase, but the… Expand
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Highly Cited
2001
Highly Cited
2001
Pin1 acts catalytically to promote a conformational change in Cdc25.
Pin1 is an essential protein that can peptidyl-prolyl-isomerize small phosphopeptides. It has been suggested that Pin1 regulates… Expand
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Highly Cited
2000
Highly Cited
2000
The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.
A checkpoint operating in the G(2) phase of the cell cycle prevents entry into mitosis in the presence of DNA damage. UCN-01, a… Expand
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Highly Cited
1998
Highly Cited
1998
The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1.
The cis/trans peptidyl-prolyl isomerase, Pin1, is a regulator of mitosis that is well conserved from yeast to man. Here we… Expand
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Highly Cited
1996
Highly Cited
1996
Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts.
Cdc2, the cyclin-dependent kinase that controls mitosis, is negatively regulated by phosphorylation on its threonine-14 and… Expand
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Highly Cited
1996
Highly Cited
1996
Identification of Grf1 on mouse chromosome 9 as an imprinted gene by RLGS–M
Normal mammalian development requires a diploid combination of both haploid parental genomes1. Uniparental disomy for certain… Expand
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Highly Cited
1993
Highly Cited
1993
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
A human complementary DNA was isolated that encodes a widely expressed protein, hSos1, that is closely related to Sos, the… Expand
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Highly Cited
1993
Highly Cited
1993
Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos.
To contribute to a deeper understanding of M-phase control in eukaryotic cells, we have constructed a model based on the… Expand
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