Ran guanyl-nucleotide exchange factor activity

Known as: RCC1 
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ran family. Under normal cellular physiological conditions, the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
024619902017

Papers overview

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2013
2013
The formation of an activity gradient of the small G-protein Ran around chromatin depends on the differential partitioning of the… (More)
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Highly Cited
2010
Highly Cited
2010
The small GTPase Ran enzyme regulates critical eukaryotic cellular functions including nuclear transport and mitosis through the… (More)
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2008
2008
RCC1 is the only known exchange factor for the Ran guanosine triphosphatase and performs essential roles in nuclear transport… (More)
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2003
2003
The RanGTP gradient across the interphase nuclear envelope and on the condensed mitotic chromosomes is essential for many… (More)
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2003
2003
BACKGROUND Both caffeine and the inactivation of RCC1, the guanine-nucleotide exchange factor (GEF) of Ran, induce premature… (More)
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Highly Cited
2001
Highly Cited
2001
The Ran guanosine triphosphatase (GTPase) controls nucleocytoplasmic transport, mitotic spindle formation, and nuclear envelope… (More)
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2000
2000
RCC1, the only known guanine-nucleotide exchange factor for the Ran GTPase, is an approximately 45-kD nuclear protein that can… (More)
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1996
1996
Charged amino acid residues of human RCC1 were converted to alanine and mutants which were unable to complement tsBN2 cells (a… (More)
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Highly Cited
1995
Highly Cited
1995
The guanine nucleotide dissociation and GTPase reactions of Ran, a Ras-related nuclear protein, have been investigated using… (More)
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Highly Cited
1995
Highly Cited
1995
The interaction of Ran, a Ras-related nuclear GTP-binding protein, with its guanine nucleotide exchange factor RCC1 has been… (More)
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