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Rad51 Recombinase

Known as: RAD51 Protein, Rad51 Recombinase [Chemical/Ingredient], Recombinase, Rad51 
A Rec A recombinase found in eukaryotes. Rad51 is involved in DNA REPAIR of double-strand breaks.
National Institutes of Health

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In BloodProcess of secretionRAD51 geneantagonists & inhibitors
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Papers overview

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Highly Cited
2017
Highly Cited
2017
Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange
The central step in eukaryotic homologous recombination (HR) is ATP-dependent DNA-strand exchange mediated by the Rad51… Expand
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2016
2016
Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics
Significance Homologous recombination provides the most accurate means to repair genotoxic DNA lesions. It depends on the… Expand
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2007
2007
Transcriptional profile of the homologous recombination machinery and characterization of the EhRAD51 recombinase in response to DNA damage in Entamoeba histolytica
BackgroundIn eukaryotic and prokaryotic cells, homologous recombination is an accurate mechanism to generate genetic diversity… Expand
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Highly Cited
2006
Highly Cited
2006
Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase function.
The Rad51 recombinase polymerizes on ssDNA to yield a right-handed nucleoprotein filament, called the presynaptic filament, that… Expand
Highly Cited
2004
Highly Cited
2004
Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchange
Homologous recombination is crucial for the repair of DNA breaks and maintenance of genome stability. In Escherichia coli… Expand
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Highly Cited
2004
Highly Cited
2004
Conformational changes modulate the activity of human RAD51 protein.
Homologous recombination provides a major pathway for the repair of DNA double-strand breaks in mammalian cells. Defects in… Expand
Highly Cited
2002
Highly Cited
2002
Structure of the single-strand annealing domain of human RAD52 protein
In eukaryotic cells, RAD52 protein plays a central role in genetic recombination and DNA repair by (i) promoting the annealing of… Expand
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Highly Cited
1997
Highly Cited
1997
Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase.
  • P. Sung
  • Genes & development
  • 1997
    • Corpus ID: 42929556
Saccharomyces cerevisiae RAD51, RAD55, and RAD57 genes, required for genetic recombination and DNA double-strand-break repair… Expand
Highly Cited
1996
Highly Cited
1996
Yeast Rad51 Recombinase Mediates Polar DNA Strand Exchange in the Absence of ATP Hydrolysis*
Saccharomyces cerevisiae RAD51 gene is required for genetic recombination and recombinational repair of DNA strand breaks. Rad51… Expand
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Highly Cited
1994
Highly Cited
1994
Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein.
  • P. Sung
  • Science
  • 1994
    • Corpus ID: 23615292
The RAD51 gene of Saccharomyces cerevisiae is required for genetic recombination and DNA double-strand break repair. Here it is… Expand
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