FAQ

Rad51 Recombinase

Known as: RAD51 Protein, Rad51 Recombinase [Chemical/Ingredient], Recombinase, Rad51 
A Rec A recombinase found in eukaryotes. Rad51 is involved in DNA REPAIR of double-strand breaks.
National Institutes of Health

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1992-2018
024619922018

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In BloodProcess of secretionRAD51 geneantagonists & inhibitors
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Rad51 protein, S pombe

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Rad51 Recombinase
physiological aspects
In Blood
chemical synthesis
RAD51 gene
standards characteristics

Papers overview

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2017
2017
Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange
The central step in eukaryotic homologous recombination (HR) is ATP-dependent DNA-strand exchange mediated by the Rad51… (More)
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2016
2016
Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics.
The DNA strand exchange protein RAD51 facilitates the central step in homologous recombination, a process fundamentally important… (More)
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2007
2007
Transcriptional profile of the homologous recombination machinery and characterization of the EhRAD51 recombinase in response to DNA damage in Entamoeba histolytica
In eukaryotic and prokaryotic cells, homologous recombination is an accurate mechanism to generate genetic diversity, and it is… (More)
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Highly Cited
2006
Highly Cited
2006
Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase function.
The Rad51 recombinase polymerizes on ssDNA to yield a right-handed nucleoprotein filament, called the presynaptic filament, that… (More)
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2004
2004
Conformational changes modulate the activity of human RAD51 protein.
Homologous recombination provides a major pathway for the repair of DNA double-strand breaks in mammalian cells. Defects in… (More)
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2002
2002
Mutations in yeast Rad51 that partially bypass the requirement for Rad55 and Rad57 in DNA repair by increasing the stability of Rad51-DNA complexes.
Yeast Rad51 promotes homologous pairing and strand exchange in vitro, but this activity is inefficient in the absence of the… (More)
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2002
2002
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53.
BLM, WRN, and p53 are involved in the homologous DNA recombination pathway. The DNA structure-specific helicases, BLM and WRN… (More)
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Highly Cited
1997
Highly Cited
1997
Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase.
Saccharomyces cerevisiae RAD51, RAD55, and RAD57 genes, required for genetic recombination and DNA double-strand-break repair… (More)
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Highly Cited
1996
Highly Cited
1996
Yeast Rad51 recombinase mediates polar DNA strand exchange in the absence of ATP hydrolysis.
Saccharomyces cerevisiae RAD51 gene is required for genetic recombination and recombinational repair of DNA strand breaks. Rad51… (More)
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Highly Cited
1994
Highly Cited
1994
Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein.
The RAD51 gene of Saccharomyces cerevisiae is required for genetic recombination and DNA double-strand break repair. Here it is… (More)
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