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RWJ 54428

Known as: RWJ-54428 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Cephalosporins

Narrower (1)

MC-02,479

Papers overview

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Review
2009
Review
2009
Beta-lactams and Beta-lactamase-inhibitors in current- or potential-clinical practice: A comprehensive update
The use of successive generations of β-lactams has selected successive generations of β-lactamases including CTX-M ESBLs, AmpC… 
2008
2008
Pharmacodynamics of RWJ-54428 against Staphylococcus aureus, Streptococcus pneumoniae, and Enterococcus faecalis in a Neutropenic Mouse Thigh Infection Model
ABSTRACT RWJ-54428 (also known as MC-02,479) is a new cephalosporin with promising activity against gram-positive bacteria. The… 
Review
2005
Review
2005
Investigational new drugs for the treatment of resistant pneumococcal infections
Antibiotic resistance in Streptococcus pneumoniae is not only increasing with penicillin but also with other antimicrobial… 
2003
2003
In Vivo Antibacterial Activity of RWJ-54428, a New Cephalosporin with Activity against Gram-Positive Bacteria
ABSTRACT RWJ-54428 (MC-02,479) is a new cephalosporin with activity against resistant gram-positive organisms, including… 
2003
2003
RWJ-54428 (MC-02,479), a New Cephalosporin with High Affinity for Penicillin-Binding Proteins, Including PBP 2a, and Stability to Staphylococcal Beta-Lactamases
ABSTRACT RWJ-54428 (MC-02,479) is a new cephalosporin active against gram-positive bacteria, including methicillin-resistant… 
2002
2002
In Vitro Activity of Cephalosporin RWJ-54428 (MC-02479) against Multidrug-Resistant Gram-Positive Cocci
ABSTRACT RWJ-54428 (MC-02479) is a novel cephalosporin that binds to penicillin-binding protein (PBP) PBP 2′ (PBP 2a) of… 
2002
2002
In vitro activity of a new cephalosporin, RWJ-54428, against streptococci, enterococci and staphylococci, including glycopeptide-intermediate Staphylococcus aureus.
The need for new antimicrobial agents with activity against Gram-positive organisms has become increasingly important because of… 
Review
2001
Review
2001
In Vitro Activities of RWJ-54428 (MC-02,479) against Multiresistant Gram-Positive Bacteria
ABSTRACT RWJ-54428 (MC-02,479) is a new cephalosporin with a high level of activity against gram-positive bacteria. In a broth… 
2000
2000
Discovery of RWJ-54428 (MC-02,479), a new cephalosporin active against resistant gram-positive bacteria.
The discovery of RWJ-54428 (MC-02,479), a new cephalosporin displaying promising activity against sensitive and resistant Gram… 
Review
1999
Review
1999
Antibiotic resistance versus small molecules, the chemical evolution
Two discovery approaches directed to addressing the problem of increasing bacterial resistance are described. The first is a… 
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