RPA2 gene

Known as: Replication Protein A2, 32kDa Gene, RPA32, REPLICATION PROTEIN A2, 32-KD 
This gene is involved in DNA repair, recombination and replication.
National Institutes of Health

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6 relations
DNA RepairDNA ReplicationRecombination, GeneticReplication Protein A 32 kDa Subunit
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Papers overview

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2012
2012
Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication.
We have discovered that 3,3',5-triiodothyronine (T3) inhibits binding of a PIP-box sequence peptide to proliferating cell nuclear… (More)
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2011
2011
Activation of DNA damage response pathways in human mesenchymal stem cells exposed to cisplatin or γ-irradiation.
DNA damaging agents are widely used in treatment of hematogical malignancies and solid tumors. While effects on hematopoietic… (More)
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Highly Cited
2010
Highly Cited
2010
A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination
Double-stranded DNA breaks (DSBs) induce a phosphorylation-mediated signaling cascade, but the role of phosphatases in this… (More)
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Highly Cited
2006
Highly Cited
2006
Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinoma.
Human papillomavirus (HPV) is associated with a subset of head and neck squamous cell carcinoma (HNSCC). Between 15% and 35% of… (More)
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Highly Cited
2006
Highly Cited
2006
RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint.
Upon DNA damage, replication is inhibited by the S-phase checkpoint. ATR (ataxia telangiectasia mutated- and Rad3-related) is… (More)
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2005
2005
Arabidopsis RPA2: A Genetic Link among Transcriptional Gene Silencing, DNA Repair, and DNA Replication
Transcriptional gene silencing (TGS) controls the expression of transposable elements and of endogenous genes containing promoter… (More)
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Highly Cited
2005
Highly Cited
2005
The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability.
Fanconi anemia (FA) is a rare multi-genic, autosomal and X-linked recessive disorder characterized by hematological abnormalities… (More)
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2004
2004
DNA repair in higher plants; photoreactivation is the major DNA repair pathway in non-proliferating cells while excision repair (nucleotide excision repair and base excision repair) is active in…
We investigated expression patterns of DNA repair genes such as the CPD photolyase, UV-DDB1, CSB, PCNA, RPA32 and FEN-1 genes by… (More)
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2004
2004
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.
Replication protein A (RPA) is a single-stranded DNA (ssDNA) binding protein involved in various processes, including nucleotide… (More)
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Highly Cited
1997
Highly Cited
1997
Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function.
7-Hydroxystaurosporine (UCN-01) is a selective protein kinase C inhibitor in clinical trial for cancer treatment. In this study… (More)
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