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RP 62203

Known as: RP-62203 
 
National Institutes of Health

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1 relation

Broader (1)

fananserin

Papers overview

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2018
2018
The Involvement of 5-HT 2A Receptor in the Regulation of Sleep and Wakefulness, and the Potential Therapeutic Use of Selective 5-HT 2A Receptor Antagonists and Inverse Agonists for the Treatment of…
Several agents have been shown to improve sleep induction and/or maintenance in patients with primary or comorbid insomnia. These… Expand
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1998
1998
Selective blockade of serotonin2C/2B receptors enhances dopamine release in the rat nucleus accumbens
The effects of mesulergine (100 and 200 microg/kg s.c.), SB 206553 (1 and 2.5 mg/kg i.p.), RP 62203 (2.5 and 4 mg/kg i.p.) and… Expand
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1997
1997
Role of 5-HT2A and 5-HT2C Receptor Subtypes in the Two Types of Fear Generated by the Elevated T-Maze
To study the role of 5-HT2A and 5-HT2C receptor subtypes in anxiety, the behavioral effects of drugs that either block or… Expand
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1996
1996
The naphtosultam derivative RP 62203 (fananserin) has high affinity for the dopamine D4 receptor.
The dopamine D4 receptor is a potential target for novel antipsychotic drugs. Most available compounds with affinity for the… Expand
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1993
1993
Autoradiographic studies of RP 62203, a potent 5-HT2 receptor antagonist. Pharmacological characterization of [3H]RP 62203 binding in the rat brain.
The binding properties and localization of [3H]RP 62203, a novel ligand for 5-HT2 receptors, were investigated on rat brain… Expand
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1993
1993
Autoradiographic studies of RP 62203, a potent 5-HT2 receptor antagonist. In vitro and ex vivo selectivity profile.
In this study, quantitative autoradiography was used to determine the selectivity of RP 62203, a novel naphtosultam derivative… Expand
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1992
1992
Pharmacological characterization of RP 62203, a novel 5-hydroxytryptamine 5-HT2 receptor antagonist.
1. RP 62203 (2-[3-(4-(4-fluorophenyl)-piperazinyl)propyl]naphto[1,8- ca]isothiazole-1,1-dioxide) is a novel naphtosultam… Expand
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1992
1992
RP 62203, a 5-hydroxytryptamine2 antagonist, enhances deep NREM sleep in rats.
RP 62203, a naphtosultam derivative, is an antagonist at the 5-hydroxytryptamine2 (HT2) receptor. The sleep pattern of rats… Expand
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1991
1991
Are 5-HT2 antagonists endowed with anxiolytic properties in rodents?
The precise role of serotonin (5-HT) in anxiety remains unclear. We report here on the effects of RP 62203, a new 5-HT2… Expand
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1991
1991
The novel 5-HT2 receptor antagonist, RP 62203, selectively blocks serotoninergic but not dopaminergic-induced inhibition in the rat prefrontal cortex.
The influence of the novel 5-hydroxytryptamine2 (5-HT2) receptor antagonist, RP 62203, on serotoninergic neurotransmission was… Expand
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