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RNR Inhibitor COH29
Known as:
COH29
, Ribonucleotide Reductase Holoenzyme Inhibitor COH29
An orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic…
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National Institutes of Health
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Related topics
Related topics
4 relations
DNA Synthesis Inhibition
Nucleotide Biosynthesis
Positive Regulation of Apoptosis
Ribonucleotide Reductase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
A phase I study to assess the safety, pharmacokinetics (PK), pharmacodynamics (PD), and anti-tumor activity of oral COH29, a novel ribonucleotide reductase (RNR) inhibitor in adult patients (pts…
J. Chao
,
T. Synold
,
+9 authors
L. Malkas
2017
Corpus ID: 79649892
TPS2600Background: Human RNR catalyzes the rate-limiting step in the formation of deoxyribonucleotide triphosphates (dNTPs…
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2011
2011
Abstract 3258: Development of novel ribonucleotide reductase inhibitors: A story from structural analysis to preclinical study
Bingsen Zhou
,
L. Su
,
Yate-Ching Yuan
,
Shuya Hu
,
Y. Yen
2011
Corpus ID: 75159747
The goal of this project is to develop new class inhibitors for Ribonucleotide Reductase (RR), a key enzyme for DNA synthesis…
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