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RNR Inhibitor COH29

Known as: COH29, Ribonucleotide Reductase Holoenzyme Inhibitor COH29 
An orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic… Expand
National Institutes of Health

Papers overview

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2019
2019
Purpose: Defects in genes in the DNA repair pathways significantly contribute to prostate cancer progression. We hypothesize that… Expand
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2017
2017
TPS2600Background: Human RNR catalyzes the rate-limiting step in the formation of deoxyribonucleotide triphosphates (dNTPs… Expand
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2016
2016
Macroautophagy can promote cellular survival or death depending on the cellular context and its extent. We hypothesized that… Expand
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2015
2015
COH29 [N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide], a novel antimetabolite drug developed at City of… Expand
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2014
2014
BackgroundRibonucleotide reductase (RR) is an essential enzyme involved in DNA synthesis. We hypothesized that RR subunit M2… Expand
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2013
2013
Ribonucleotide reductase (RNR) is an attractive target for anticancer agents given its central function in DNA synthesis, growth… Expand
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2011
2011
The goal of this project is to develop new class inhibitors for Ribonucleotide Reductase (RR), a key enzyme for DNA synthesis… Expand
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