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RNR Inhibitor COH29

Known as: COH29, Ribonucleotide Reductase Holoenzyme Inhibitor COH29 
An orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic… Expand
National Institutes of Health

Related topics

Related topics

4 relations
DNA Synthesis InhibitionNucleotide BiosynthesisPositive Regulation of ApoptosisRibonucleotide Reductase

Papers overview

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2019
2019
A Novel Mechanism Driving Poor-Prognosis Prostate Cancer: Overexpression of the DNA Repair Gene, Ribonucleotide Reductase Small Subunit M2 (RRM2)
Purpose: Defects in genes in the DNA repair pathways significantly contribute to prostate cancer progression. We hypothesize that… Expand
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2017
2017
A phase I study to assess the safety, pharmacokinetics (PK), pharmacodynamics (PD), and anti-tumor activity of oral COH29, a novel ribonucleotide reductase (RNR) inhibitor in adult patients (pts…
TPS2600Background: Human RNR catalyzes the rate-limiting step in the formation of deoxyribonucleotide triphosphates (dNTPs… Expand
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2016
2016
Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells
Macroautophagy can promote cellular survival or death depending on the cellular context and its extent. We hypothesized that… Expand
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2015
2015
The Novel Ribonucleotide Reductase Inhibitor COH29 Inhibits DNA Repair In Vitro
COH29 [N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide], a novel antimetabolite drug developed at City of… Expand
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2014
2014
Prognostic and therapeutic significance of ribonucleotide reductase small subunit M2 in estrogen-negative breast cancers
BackgroundRibonucleotide reductase (RR) is an essential enzyme involved in DNA synthesis. We hypothesized that RR subunit M2… Expand
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2013
2013
A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance.
Ribonucleotide reductase (RNR) is an attractive target for anticancer agents given its central function in DNA synthesis, growth… Expand
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2011
2011
Abstract 3258: Development of novel ribonucleotide reductase inhibitors: A story from structural analysis to preclinical study
The goal of this project is to develop new class inhibitors for Ribonucleotide Reductase (RR), a key enzyme for DNA synthesis… Expand
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