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RNR Inhibitor COH29

Known as: COH29, Ribonucleotide Reductase Holoenzyme Inhibitor COH29 
An orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic… 
National Institutes of Health

Papers overview

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Highly Cited
2019
Highly Cited
2019
Purpose: Defects in genes in the DNA repair pathways significantly contribute to prostate cancer progression. We hypothesize that… 
2017
2017
TPS2600Background: Human RNR catalyzes the rate-limiting step in the formation of deoxyribonucleotide triphosphates (dNTPs… 
2015
2015
COH29 [N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide], a novel antimetabolite drug developed at City of… 
2015
2015
Macroautophagy can promote cellular survival or death depending on the cellular context and its extent. We hypothesized that… 
2014
2014
Ribonucleotide reductase (RR) is an essential enzyme involved in DNA synthesis. We hypothesized that RR subunit M2 (RRM2) might… 
Highly Cited
2013
Highly Cited
2013
Ribonucleotide reductase (RNR) is an attractive target for anticancer agents given its central function in DNA synthesis, growth… 
2011
2011
The goal of this project is to develop new class inhibitors for Ribonucleotide Reductase (RR), a key enzyme for DNA synthesis…