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RNR Inhibitor COH29
Known as:
COH29
, Ribonucleotide Reductase Holoenzyme Inhibitor COH29
An orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic…
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National Institutes of Health
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Related topics
Related topics
4 relations
DNA Synthesis Inhibition
Nucleotide Biosynthesis
Positive Regulation of Apoptosis
Ribonucleotide Reductase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
A Novel Mechanism Driving Poor-Prognosis Prostate Cancer: Overexpression of the DNA Repair Gene, Ribonucleotide Reductase Small Subunit M2 (RRM2)
Ying Z. Mazzu
,
J. Armenia
,
+18 authors
P. Kantoff
Clinical Cancer Research
2019
Corpus ID: 121318595
Purpose: Defects in genes in the DNA repair pathways significantly contribute to prostate cancer progression. We hypothesize that…
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2017
2017
A phase I study to assess the safety, pharmacokinetics (PK), pharmacodynamics (PD), and anti-tumor activity of oral COH29, a novel ribonucleotide reductase (RNR) inhibitor in adult patients (pts…
J. Chao
,
T. Synold
,
+9 authors
L. Malkas
2017
Corpus ID: 79649892
TPS2600Background: Human RNR catalyzes the rate-limiting step in the formation of deoxyribonucleotide triphosphates (dNTPs…
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2015
2015
The Novel Ribonucleotide Reductase Inhibitor COH29 Inhibits DNA Repair In Vitro
M. Chen
,
Bingsen Zhou
,
+17 authors
Y. Yen
Molecular Pharmacology
2015
Corpus ID: 7487971
COH29 [N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide], a novel antimetabolite drug developed at City of…
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2015
2015
Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells
Yun-Ru Chen
,
B. Tsou
,
+4 authors
D. Ann
OncoTarget
2015
Corpus ID: 431160
Macroautophagy can promote cellular survival or death depending on the cellular context and its extent. We hypothesized that…
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2014
2014
Prognostic and therapeutic significance of ribonucleotide reductase small subunit M2 in estrogen-negative breast cancers
Hang Zhang
,
Xiyong Liu
,
+7 authors
Y. Yen
BMC Cancer
2014
Corpus ID: 255808923
Ribonucleotide reductase (RR) is an essential enzyme involved in DNA synthesis. We hypothesized that RR subunit M2 (RRM2) might…
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Highly Cited
2013
Highly Cited
2013
A small-molecule blocking ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance.
Bingsen Zhou
,
L. Su
,
+9 authors
Y. Yen
Cancer Research
2013
Corpus ID: 1169758
Ribonucleotide reductase (RNR) is an attractive target for anticancer agents given its central function in DNA synthesis, growth…
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2011
2011
Abstract 3258: Development of novel ribonucleotide reductase inhibitors: A story from structural analysis to preclinical study
Bingsen Zhou
,
L. Su
,
Yate-Ching Yuan
,
Shuya Hu
,
Y. Yen
2011
Corpus ID: 75159747
The goal of this project is to develop new class inhibitors for Ribonucleotide Reductase (RR), a key enzyme for DNA synthesis…
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