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RNF145 gene

Known as: FLJ31951, RNF145, ring finger protein 145 
 
National Institutes of Health

Related topics

Related topics

1 relation
RNF14 gene

Papers overview

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2018
2018
Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase
Cholesterol biosynthesis is tightly regulated in the cell. For example, high sterol concentrations can stimulate degradation of… Expand
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2018
Review
2018
The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1
Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target… Expand
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2017
2017
Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP
Cholesterol homeostasis is maintained through concerted action of the SREBPs and LXRs. Here, we report that RNF145, a previously… Expand
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2017
2017
Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene
Cellular cholesterol metabolism is subject to tight regulation to maintain adequate levels of this central lipid molecule. Herein… Expand
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2015
2015
Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst
The phagocyte oxidative burst, mediated by Nox2 NADPH oxidase-derived reactive oxygen species, confers host defense against a… Expand
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2009
2009
Detection of Cytogenetic Abnormalities Associated with Outcome Differences in Acute Myeloid Leukemia Using Array-Based Comparative Genomic Hybridization (aCGH) Analysis.
Abstract 1633 Poster Board I-659 Background The presence of abnormal cytogenetic findings at diagnosis is an independent… Expand
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