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RK 682

Known as: RK-682, RK682 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Protein phosphatase
antagonists & inhibitors

Papers overview

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2015
2015
Focused library with a core structure extracted from natural products and modified: application to phosphatase inhibitors and several biochemical findings.
Synthesis of a focused library is an important strategy to create novel modulators of specific classes of proteins. Compounds in… 
2015
2015
tion of a-pyrone ring formation in myxopyronin biosynthesis †
Department of Microbial Natural Products Research Saarland, Building C2 3, 6612 mueller@helmholtz-hzi.de Department of Drug… 
2013
2013
Synthesis of Six-membered Ring Analogues of RK-682 and Meldrum’s acid derivatives. Evaluation on the Inhibition of Protein Tyrosine Phosphatases
Protein tyrosine phosphatases (PTPs) together with protein tyrosine kinases (PTKs) regulate protein tyrosine phosphorylation… 
2010
2010
Baculovirus expression system: An alternative for producing catalytically active human PTP-1B
Protein tyrosine phosphatases (PTPs) play multiple roles in many physiological processes. Over-expression of the PTPs has been… 
2009
2009
A cell-based screening to detect inhibitors of BRAF signaling pathway
BRAF, a serine/threonine kinase, regulates the mitogen-activated protein kinase (RAS/RAF/MEK/ERK) pathway, which is involved in… 
Review
2006
Review
2006
Domino syntheses of bioactive tetronic and tetramic acids
Natural products containing tetronic acid or tetramic acid moieties continue to attract the interest of chemists, biologists, and… 
2006
2006
P-335 SYNTHESIS OF RK-682 ENAMIDE DERIVATIVES AS NOVEL DUAL-SPECIFICITY PROTEIN PHOSPHATASE INHIBITORS
2003
2003
Conversion of Ca2+ salt of an organic compound to its Li+ salt to simplify the fast atom bombardment mass spectrum.
The FAB mass spectrum of the Ca(2+) salt of RK-682 (1, MW 368), a potent protein tyrosine phosphatase inhibitor, shows a complex… 
2001
2001
Asymmetric synthesis of a 3-acyltetronic acid derivative, RK-682, and formation of its calcium salt during silica gel column chromatography.
RK-682 was reported to be a potent protein tyrosine phosphatase inhibitor. We found that (R)-3-hexadecanoyl-5… 
1997
1997
Okadaic Acid, RK682 and Calyculin Modulate TcR - Mediated Signaling Events
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