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RIN1 gene

Known as: RAS INHIBITOR 1, RIN1, Ras and Rab interactor 1 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR
Summary Stimulation of epidermal growth factor receptor (EGFR) initiates RAS signaling simultaneously with EGFR internalization… 
Highly Cited
2009
Highly Cited
2009
Rab5 Isoforms Differentially Regulate the Trafficking and Degradation of Epidermal Growth Factor Receptors*
Ligand-mediated endocytosis is an intricate regulatory mechanism for epidermal growth factor receptor (EGFR) signal transduction… 
2009
2009
Cell Proliferation and Epidermal Growth Factor Signaling in Non-small Cell Lung Adenocarcinoma Cell Lines Are Dependent on Rin1
Rin1 is a Rab5 guanine nucleotide exchange factor that plays an important role in Ras-activated endocytosis and growth factor… 
Highly Cited
2008
Highly Cited
2008
The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons
Ephrin signaling through Eph receptor tyrosine kinases regulates important morphogenetic events during development and synaptic… 
2007
2007
Rin1 Interacts with Signal-transducing Adaptor Molecule (STAM) and Mediates Epidermal Growth Factor Receptor Trafficking and Degradation*
Rin1, the prototype of a new family of multidomain Rab5 exchange factors, has been shown to play an important role in the… 
Highly Cited
2003
Highly Cited
2003
The Src Homology 2 Domain of Rin1 Mediates Its Binding to the Epidermal Growth Factor Receptor and Regulates Receptor Endocytosis*
Activated epidermal growth factor receptors (EGFRs) recruit intracellular proteins that mediate receptor signaling and endocytic… 
Highly Cited
2000
Highly Cited
2000
A consistent pattern of RIN1 rearrangements in oral squamous cell carcinoma cell lines supports a breakage‐fusion‐bridge cycle model for 11q13 amplification
Gene amplification is a common feature of tumors. Overexpression of some amplified genes plays a role in tumor progression. Gene… 
Highly Cited
1997
Highly Cited
1997
Protein binding and signaling properties of RIN1 suggest a unique effector function.
Human RIN1 was first characterized as a RAS binding protein based on the properties of its carboxyl-terminal domain. We now show… 
Highly Cited
1997
Highly Cited
1997
Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1.
Highly Cited
1995
Highly Cited
1995
A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1
The overexpression of some human proteins can cause interference with the Ras signal transduction pathway in the yeast… 
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