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RHBDF2 gene

Known as: FLJ22341, RHBDL5, IRHOM2 
 
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Proteolytic cleavage and release from the cell surface of membrane-tethered ligands is an important mechanism of regulating… Expand
2017
2017
Summary Cell surface metalloproteases coordinate signaling during development, tissue homeostasis, and disease. TACE (TNF… Expand
Highly Cited
2016
Highly Cited
2016
STING is a central adaptor in the innate immune response to DNA viruses. However, the manner in which STING activity is regulated… Expand
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2015
2015
Without the N terminus, iRhom proteins cannot properly limit ADAM17 activity, resulting in impaired cancer cell death. Tumor… Expand
Highly Cited
2014
Highly Cited
2014
iRHOM2 is a highly conserved, catalytically inactive member of the Rhomboid family, which has recently been shown to regulate the… Expand
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2014
2014
Significance Epidermal growth factor receptor (EGFR) signal transduction plays a major role in growth, proliferation, and… Expand
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Highly Cited
2013
Highly Cited
2013
Loss of iRhom2, a catalytically inactive rhomboid‐like protein, blocks maturation of TACE/ADAM17 in macrophages, resulting in… Expand
Highly Cited
2013
Highly Cited
2013
iRHOM2, encoded by the gene Rhbdf2, regulates the maturation of the TNF-α convertase (TACE), which controls shedding of TNF-α and… Expand
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Highly Cited
2012
Highly Cited
2012
TACE Trafficking The cytokine tumor necrosis factor (TNF) is a major driver of inflammation and contributes to the immune… Expand
1980
1980
Tocainide, a lidocaine congener with low hepatic clearance, is eliminated predominantly by formation of a novel glucuronide… Expand