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RHBDF2 gene

Known as: FLJ22341, RHBDL5, IRHOM2 
 
National Institutes of Health

Papers overview

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2017
2017
VISA (also known as MAVS, IPS-1 and Cardif) is an essential adaptor protein in innate immune response to RNA virus. The protein… Expand
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2016
2016
STING is a central adaptor in the innate immune response to DNA viruses. However, the manner in which STING activity is regulated… Expand
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2014
2014
The rhomboid 5 homolog 2 (Rhbdf2) gene encodes an inactive rhomboid (iRhom) protease, iRhom2, one of a family of enzymes… Expand
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2014
2014
iRHOM2 is a highly conserved, catalytically inactive member of the Rhomboid family, which has recently been shown to regulate the… Expand
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2014
2014
iRhoms are closely related to rhomboid intramembrane proteases but lack catalytic activity. In mammals iRhoms are known to… Expand
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Highly Cited
2013
Highly Cited
2013
iRHOM2, encoded by the gene Rhbdf2, regulates the maturation of the TNF-α convertase (TACE), which controls shedding of TNF-α and… Expand
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Highly Cited
2013
Highly Cited
2013
Loss of iRhom2, a catalytically inactive rhomboid-like protein, blocks maturation of TACE/ADAM17 in macrophages, resulting in… Expand
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2013
2013
The cytokine TNF-α is a major drug target for rheumatoid arthritis, an inflammatory joint disorder. An alternative approach is to… Expand
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Highly Cited
2012
Highly Cited
2012
The cytokine tumor necrosis factor (TNF) is the primary trigger of inflammation. Like many extracellular signaling proteins, TNF… Expand
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2005
2005
Loss of heterozygosity (LOH) analysis was performed in epithelial ovarian cancers (EOC) to further characterize a previously… Expand
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