RASGRP1 gene

Known as: RASGRP, RAS GUANYL NUCLEOTIDE-RELEASING PROTEIN 1, RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) Gene 
This gene plays a role in guanine nucleotide exchange.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Substantial progress has been made in identification of type 2 diabetes (T2D) risk loci in the past few years, but our… (More)
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Highly Cited
2012
Highly Cited
2012
Close to 50 genetic loci have been associated with type 2 diabetes (T2D), but they explain only 15% of the heritability. In an… (More)
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Highly Cited
2010
Highly Cited
2010
Systemic lupus erythematosus is a complex autoimmune disease caused by genetic and epigenetic alterations. DNA methylation… (More)
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Highly Cited
2008
Highly Cited
2008
At present, there is no method available to predict response to farnesyltransferase inhibitors (FTIs). We analyzed gene… (More)
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Highly Cited
2005
Highly Cited
2005
Ras GTPases are on/off switches regulating numerous cellular responses by signaling to various effector molecules. In T… (More)
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2005
2005
RasGRP1 is a Ras-specific exchange factor, which is activated by T-cell receptor (TCR) and promotes TCR-dependent positive… (More)
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2004
2004
Vav1 is a signaling protein required for both positive and negative selection of CD4(+)CD8(+) double positive thymocytes… (More)
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Highly Cited
2003
Highly Cited
2003
Ras proteins regulate cellular growth and differentiation, and are mutated in 30% of cancers. We have shown recently that Ras is… (More)
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Highly Cited
2003
Highly Cited
2003
Ras proteins regulate cellular growth and differentiation, and are mutated in 30% of cancers. We have shown recently that Ras is… (More)
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Highly Cited
2002
Highly Cited
2002
Two important Ras-guanyl nucleotide exchange factors, Sos and RasGRP1, control Ras activation in thymocytes. However, the… (More)
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