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RAG2 wt Allele

Known as: RAG-2, Recombination Activating Gene 2 wt Allele, V(D)J Recombination-Activating Protein 2 Gene 
Human RAG2 wild-type allele is located in the vicinity of 11p13 and is approximately 6 kb in length. This allele, which encodes V(D)J recombination… 
National Institutes of Health

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11p13Immune System ProcessesV(D)J RecombinationV(D)J recombination activating protein 2

Papers overview

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2002
2002
Combinatorial regulation of the murine RAG-2 promoter by Sp1 and distinct lymphocyte-specific transcription factors.
1998
1998
2,3,7,8-Tetrachlorodibenzo-p-dioxin and diethylstilbestrol affect thymocytes at different stages of development in fetal thymus organ culture.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and estrogen induce thymic atrophy and alter thymocyte development. In the present… 
1997
1997
RAG-1 and RAG-2-dependent assembly of functional complexes with V(D)J recombination substrates in solution
V(D)J recombination is initiated by RAG-1 and RAG-2, which introduce double-strand DNA breaks at recombination signal sequences… 
1996
1996
Immature T cells in peripheral lymphoid organs of recombinase-activating gene-1/-2-deficient mice. Thymus dependence and responsiveness to anti-CD3 epsilon antibody.
Thymocytes of mice deficient in the recombinase-activating gene (RAG)-1 or RAG-2 cannot express and receive signals through the… 
1994
1994
Regulation of RAG-2 protein expression in avian thymocytes
The recombinase-activating genes, RAG-1 and RAG-2, have been shown to be necessary to initiate the process of V(D)J recombination… 
Highly Cited
1993
Highly Cited
1993
DNA double-strand break rejoining deficiency in TK6 and other human B-lymphoblast cell lines.
TK6, WI-L2, SB and three other B-lymphoblast lines were deficient in the rejoining of DNA double-strand breaks (DSBs) induced by… 
1993
1993
Recombinase activating gene expression in thymic subpopulations. A transitional cell type has lost RAG-2 but not RAG-1.
We have used a highly sensitive Northern blot probing technique to examine RAG-1 and RAG-2 mRNA expression in unmanipulated… 
1993
1993
RAG-1 and RAG-2 are not sufficient to direct all phases of immunoglobulin gene rearrangement in pre-B-cell lines
To probe the factors controlling immunoglobulin heavy-chain gene rearrangement, we analyzed Abelson virus-transformed pre-B-cell… 
1992
1992
Expression of human recombination activating genes (RAG-1 and RAG-2) in Hodgkin's disease.
The differentiation status of Sternberg-Reed (SR) cells is still not well defined, primarily because of their scarcity in tumor… 
1991
1991
A simple technique for generating probes for RNA in situ hybridization: an adjunct to genome mapping exemplified by the RAG-1/RAG-2 gene cluster.
Two major problems have to be solved in studies of genes near breakpoints of chromosome abnormalities and in large-scale genomic… 
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