RAG1 gene

Known as: RING finger protein 74, V(D)J recombination-activating protein 1, Recombination Activating Gene 1 Gene 
Genes involved in activating the enzyme VDJ recombinase. RAG-1 is located on chromosome 11 in humans (chromosome 2 in mice) and is expressed… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The critical initial step in V(D)J recombination, binding of RAG1 and RAG2 to recombination signal sequences flanking antigen… (More)
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Highly Cited
2005
Highly Cited
2005
The V(D)J recombination reaction in jawed vertebrates is catalyzed by the RAG1 and RAG2 proteins, which are believed to have… (More)
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Highly Cited
2005
Highly Cited
2005
Amorphic mutations in the recombination activating genes RAG1 and RAG2 have been reported to cause T- B- SCID, whereas… (More)
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Highly Cited
2004
Highly Cited
2004
We determined the complete nucleotide sequence of the mitochondrial (mt) genome of five individual caecilians (Amphibia… (More)
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Highly Cited
2004
Highly Cited
2004
The muroid rodents are the largest superfamily of mammals, containing nearly one third of all mammal species. We report on a… (More)
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Highly Cited
2001
Highly Cited
2001
Omenn syndrome (OS) is an inherited disorder characterized by an absence of circulating B cells and an infiltration of the skin… (More)
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Highly Cited
1999
Highly Cited
1999
RAG1 and RAG2 initiate V(D)J recombination, the process of rearranging the antigen-binding domain of immunoglobulins and T-cell… (More)
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Highly Cited
1998
Highly Cited
1998
Immunoglobulin and T-cell-receptor genes are assembled from component gene segments in developing lymphocytes by a site-specific… (More)
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Highly Cited
1995
Highly Cited
1995
Two waves of immunoglobulin gene rearrangements, first of the heavy, then of the light chain chain gene loci form functional… (More)
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Highly Cited
1995
Highly Cited
1995
Formation of double-strand breaks at recombination signal sequences is an early step in V(D)J recombination. Here we show that… (More)
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