RAF Proto-Oncogene Serine/Threonine-Protein Kinase, human

Known as: Raf-1, EC 2.7.11.1, cRaf 
RAF proto-oncogene serine/threonine-protein kinase (648 aa, ~73 kDa) is encoded by the human RAF1 gene. This protein plays a role in cell fate and… (More)
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
The anti-Parkinson monoamine oxidase (MAO)-B inhibitor rasagiline (Azilect) was shown to possess neuroprotective activities… (More)
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Highly Cited
2003
Highly Cited
2003
Activation of ERK1/2 stimulates macroautophagy in the human colon cancer cell line HT-29 by favoring the phosphorylation of the… (More)
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Highly Cited
2003
Highly Cited
2003
The signalling cascade including Raf, mitogen-activated protein kinase (MAPK) kinase and extracellular-signal-regulated kinase… (More)
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Highly Cited
2003
Highly Cited
2003
Specialized membrane microdomains known as lipid rafts are thought to contribute to G-protein coupled receptor (GPCR) signaling… (More)
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Highly Cited
2002
Highly Cited
2002
The Raf-1 kinase activates the ERK (extracellular-signal-regulated kinase) pathway. The cyclic AMP (cAMP)-dependent protein… (More)
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Highly Cited
2001
Highly Cited
2001
Raf-1 activation is a complex process which involves plasma membrane recruitment, phosphorylation, protein-protein and lipid… (More)
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Highly Cited
1999
Highly Cited
1999
Genetic screens in Drosophila have identified p50(cdc37) to be an essential component of the sevenless receptor/mitogen-activated… (More)
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Highly Cited
1997
Highly Cited
1997
Ras is a small GTPase that cycles between an inactive GDP-bound and an active GTP-bound form. A large variety of ligands that… (More)
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Highly Cited
1994
Highly Cited
1994
MEK is a family of dual specific protein kinases which activate the extracellular signal-regulated kinases by phosphorylation of… (More)
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Highly Cited
1992
Highly Cited
1992
THE normal cellular homologue of the acutely transforming oncogene v-ra/is c-raf-l, which encodes a serine/threonine protein… (More)
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