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Bloom syndrome (BS) is an autosomal recessive disorder characterized by a high incidence of cancer and genomic instability. BLM… Expand In yeast, the Rad51-related proteins include Rad55 and Rad57, which form a heterodimer that interacts with Rad51. Five human… Expand The human Rad51 recombinase is essential for the repair of double-strand breaks in DNA that occur in somatic cells after exposure… Expand Although homologous recombination and DNA repair phenomena in bacteria were initially extensively studied without regard to any… Expand Eukaryotic cells encode two homologs of Escherichia coli RecA protein, Rad51 and Dmc1, which are required for meiotic… Expand A method was developed to examine DNA repair within the intact cell. Ultrasoft x-rays were used to induce DNA double-strand… Expand We previously identified a conserved multiprotein complex that includes hMre11 and hRad50. In this study, we used… Expand p53 is thought to function in the maintenance of genomic stability by modulating transcription and interacting with cellular… Expand Homologous pairing and strand exchange, which are catalyzed by Escherichia coli RecA protein, are central to homologous… Expand The human testis Rad51 protein, a structural homolog of E. coli RecA, binds single- and double-stranded DNA and exhibits DNA… Expand