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RAC2 gene

Known as: ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2), EN-7, RHO FAMILY, SMALL GTP-BINDING PROTEIN RAC2 
National Institutes of Health

Related topics

Related topics

1 relation
rac1 GTP-Binding Protein

Papers overview

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Highly Cited
2011
Highly Cited
2011
NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2
Objective The NOX2 NADPH oxidase complex produces reactive oxygen species and plays a critical role in the killing of microbes by… 
Highly Cited
2009
Highly Cited
2009
The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cells.
Highly Cited
2004
Highly Cited
2004
Fungal Metabolite Gliotoxin Inhibits Assembly of the Human Respiratory Burst NADPH Oxidase
ABSTRACT Reactive oxygen species are a critical weapon in the killing of Aspergillus fumigatus by polymorphonuclear leukocytes… 
Highly Cited
2003
Highly Cited
2003
Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases
The Rho guanosine triphosphatases (GTPases) Rac1 and Rac2 are critical signaling regulators in mammalian cells. The deletion of… 
Highly Cited
2001
Highly Cited
2001
Rac2 Is an Essential Regulator of Neutrophil Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Response to Specific Signaling Pathways1
Rac2 is a hematopoietic-specific Rho family GTPase implicated as an important constituent of the NADPH oxidase complex and shares… 
Highly Cited
2000
Highly Cited
2000
Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation.
A 5-week-old male infant presented with severe bacterial infections and poor wound healing, suggesting a neutrophil defect… 
Highly Cited
2000
Highly Cited
2000
Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.
Rho GTPases control a variety of cellular processes, including actin polymerization, integrin complex formation, cell adhesion… 
Highly Cited
2000
Highly Cited
2000
Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells.
Highly Cited
1994
Highly Cited
1994
Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.
Highly Cited
1994
Highly Cited
1994
Cytosolic guanine nucleotide-binding protein Rac2 operates in vivo as a component of the neutrophil respiratory burst oxidase. Transfer of Rac2 and the cytosolic oxidase components p47phox and…
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