RAC-Alpha Serine/Threonine Kinase

Known as: C-AKT, Protein Kinase B alpha, Protein Kinase B 
RAC-alpha serine/threonine-protein kinase (480 aa, ~56 kDa) is encoded by the human AKT1 gene. This protein is involved in signal transduction… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
The serine/threonine kinase Akt/PKB is a potent regulator of cell survival and has oncogenic transformation potential. Previously… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
LIM-kinase 1 (LIMK1) phosphorylates cofilin, an actin-depolymerizing factor, and regulates actin cytoskeletal reorganization… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Extracellular signals regulate actin dynamics through small GTPases of the Rho/Rac/Cdc42 (p21) family. Here we show that p21… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 4
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Using biochemical assays to determine the activation state of Rho-like GTPases, we show that the guanine nucleotide exchange… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Adhesion to ECM is required for many cell functions including cytoskeletal organization, migration, and proliferation. We… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Upon detachment from the extracellular matrix, epithelial cells enter into programmed cell death, a phenomenon known as anoikis… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
1995
Highly Cited
1995
GLYCOGEN synthase kinase-3 (GSK3)1 is implicated in the regulation of several physiological processes, including the control of… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
The Rho subfamily of GTPases is involved in control of cell morphology in mammals and yeast. The mammalian Rac and Cdc42 proteins… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Rho and rac, two members of the ras-related superfamily of small GTPases, regulate the polymerization of actin to produce stress… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
BACKGROUND Phosphoinositide 3-kinases (PI 3-kinases) are thought to play an important role in coordinating the responses elicited… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?