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R 121919

Known as: R-121919, R121919 
 

Topic mentions per year

Topic mentions per year

2000-2017
02420002017

Related topics

Related topics

2 relations
NBI 30775

Broader (1)

Pyrimidines

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
R 121919
Pyrimidines
NBI 30775

Papers overview

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2012
2012
Cell-type specific deletion of GABA(A)α1 in corticotropin-releasing factor-containing neurons enhances anxiety and disrupts fear extinction.
Corticotropin-releasing factor (CRF) is critical for the endocrine, autonomic, and behavioral responses to stressors, and it has… (More)
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2011
2011
Lithium, but not fluoxetine or the corticotropin-releasing factor receptor 1 receptor antagonist R121919, increases cell proliferation in the adult dentate gyrus.
Several antidepressant drugs have previously been reported to increase neurogenesis in the dentate gyrus of the hippocampus in… (More)
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2009
2009
Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis.
The juxtacapsular bed nucleus of the stria terminalis (jcBNST) is activated in response to basolateral amygdala (BLA) inputs… (More)
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Highly Cited
2007
Highly Cited
2007
Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats.
BACKGROUND Alcohol dependence is characterized by excessive alcohol consumption, loss of control over intake, and the presence of… (More)
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Highly Cited
2007
Highly Cited
2007
3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with…
We describe a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with advantageous properties for clinical… (More)
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2006
2006
Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats
The role of positive vs negative ethanol reinforcement in ethanol intake of Sardinian alcohol-preferring (sP) rats is unclear. To… (More)
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2003
2003
Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects.
A dysregulation of the hypothalamus-pituitary-adrenocortical (HPA) system has been hypothesized to account for a myriad of… (More)
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2002
2002
Brain Penetrance, Receptor Occupancy and Antistress In Vivo Efficacy of a Small Molecule Corticotropin Releasing Factor Type I Receptor Selective Antagonist
The present studies were designed to evaluate the competitive binding properties and functional effects of a novel nonpeptide… (More)
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2001
2001
The anxiolytic effect of the CRH(1) receptor antagonist R121919 depends on innate emotionality in rats.
Hyperactivity of central corticotropin-releasing hormone (CRH) circuits appears to contribute to the symptomatology of affective… (More)
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Highly Cited
2000
Highly Cited
2000
Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated.
Clinical and preclinical data suggest that unrestrained secretion of corticoctropin-releasing hormone (CRH) in the CNS produces… (More)
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