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QPCTL gene

Known as: FLJ20084, QPCTL, glutaminyl cyclase-like 
National Institutes of Health

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QPCT gene

Papers overview

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Highly Cited
2019
Highly Cited
2019
Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and target for cancer immunotherapy
Cancer cells can evade immune surveillance through the expression of inhibitory ligands that bind their cognate receptors on… 
2019
2019
Two insertion/deletion variants in the promoter region of the QPCTL gene are significantly associated with body weight and carcass traits in chickens.
Glutaminyl-peptide cyclotransferase-like (QPCTL) is an isoenzyme of glutaminyl-peptide cyclotransferase (QPCT). QPCTL and QPCT… 
2019
2019
High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting
Genome-scale functional genetic screens are used to identify key genetic regulators of a phenotype of interest. However, the… 
Review
2019
Review
2019
The overall potential of CD47 in cancer immunotherapy: with a focus on gastrointestinal tumors
ABSTRACT Introduction: CD47 is an anti-phagocytic (‘don’t eat me’) signal overexpressed in many malignant diseases. It acts as… 
2018
2018
A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses
Human GWAS of obesity have been successful in identifying loci associated with adiposity, but for the most part, these are non… 
2016
2016
IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes
Abstract Secretory peptides and proteins are frequently modified by pyroglutamic acid (pE, pGlu) at their N-terminus. This… 
Highly Cited
2015
Highly Cited
2015
A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity
Background:A significant proportion of severe familial forms of obesity remain genetically elusive. Taking advantage of our… 
Highly Cited
2012
Highly Cited
2012
Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations
Objective:Recent genome-wide association studies (GWAS) have identified 38 obesity-associated loci among European populations… 
Review
2012
Review
2012
What model organisms and interactomics can reveal about the genetics of human obesity
Genome-wide association studies have identified a number of genes associated with human body weight. While some of these genes… 
Highly Cited
2011
Highly Cited
2011
The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions
Acute and chronic inflammatory disorders are characterized by detrimental cytokine and chemokine expression. Frequently, the… 
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