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Pyruvate Dehydrogenase (Lipoamide)-Phosphatase

Known as: Phosphatase, Pyruvate Dehydrogenase, PDH Phosphatase, Phosphatase, PDH 
(Pyruvate dehydrogenase (lipoamide))-phosphate phosphohydrolase. A mitochondrial enzyme that catalyzes the hydrolytic removal of a phosphate on a… 
National Institutes of Health

Related topics

Related topics

10 relations
In BloodPDP1 geneProcess of secretionantagonists & inhibitors
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Broader (1)

Phosphoric Monoester Hydrolases

Narrower (1)

Pyruvate dehydrogenase phosphatase deficiency

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
In response to tenacious stress signals, such as the unscheduled activation of oncogenes, cells can mobilize tumour suppressor… 
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Highly Cited
2002
Highly Cited
2002
Evolution of mRNA polyadenylation between oocyte maturation and first embryonic cleavage in cattle and its relation with developmental competence
In this study we analyzed the pattern of polyadenylation changes that takes place between the resumption of meiosis and the first… 
Review
2001
Review
2001
Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms.
The mammalian pyruvate dehydrogenase complex (PDC) plays central and strategic roles in the control of the use of glucose-linked… 
Highly Cited
1998
Highly Cited
1998
Isoenzymes of Pyruvate Dehydrogenase Phosphatase
Pyruvate dehydrogenase phosphatase (PDP) is one of the few mammalian phosphatases residing within the mitochondrial matrix space… 
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Highly Cited
1996
Highly Cited
1996
Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution.
Protein phosphatase 2C (PP2C) is a Mn2+‐ or Mg2+‐dependent protein Ser/Thr phosphatase that is essential for regulating cellular… 
Highly Cited
1975
Highly Cited
1975
Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios.
Summary The interconversion of the active, nonphosphorylated form of pyruvate dehydrogenase and its inactive, phosphorylated form… 
Highly Cited
1974
Highly Cited
1974
Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids.
1. Monochloroacetate, dichloroacetate, trichloroacetate, difluoroacetate, 2-chloropropionate, 2,2'-dichloropropionate and 3… 
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Highly Cited
1972
Highly Cited
1972
Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase.
Highly Cited
1972
Highly Cited
1972
-Keto acid dehydrogenase complexes. XVII. Kinetic and regulatory properties of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase from bovine kidney and heart.
Abstract Both pyruvate dehydrogenase (PDH) kinase and PDH phosphatase require a divalent cation for activity. Either Mg2+ or Mn2… 
Highly Cited
1969
Highly Cited
1969
Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation.
This paper reports the discovery that the activity of the multienzyme pyruvate dehydrogenase complex from beef kidney… 
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