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Pyruvate Dehydrogenase (Lipoamide)-Phosphatase
Known as:
Phosphatase, Pyruvate Dehydrogenase
, PDH Phosphatase
, Phosphatase, PDH
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(Pyruvate dehydrogenase (lipoamide))-phosphate phosphohydrolase. A mitochondrial enzyme that catalyzes the hydrolytic removal of a phosphate on a…
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National Institutes of Health
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Related topics
Related topics
10 relations
In Blood
PDP1 gene
Process of secretion
antagonists & inhibitors
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Broader (1)
Phosphoric Monoester Hydrolases
Narrower (1)
Pyruvate dehydrogenase phosphatase deficiency
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
J. Kaplon
,
Liang Zheng
,
+9 authors
D. Peeper
Nature
2013
Corpus ID: 9323468
In response to tenacious stress signals, such as the unscheduled activation of oncogenes, cells can mobilize tumour suppressor…
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Highly Cited
2002
Highly Cited
2002
Evolution of mRNA polyadenylation between oocyte maturation and first embryonic cleavage in cattle and its relation with developmental competence
T. Brevini
,
P. Lonergan
,
+4 authors
F. Gandolfi
Molecular Reproduction and Development
2002
Corpus ID: 19361989
In this study we analyzed the pattern of polyadenylation changes that takes place between the resumption of meiosis and the first…
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Highly Cited
2001
Highly Cited
2001
Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites.
E. Kolobova
,
A. Tuganova
,
I. Boulatnikov
,
K. M. Popov
Biochemical Journal
2001
Corpus ID: 37082813
The enzymic activity of the mammalian pyruvate dehydrogenase complex is regulated by the phosphorylation of three serine residues…
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Review
2001
Review
2001
Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms.
T. Roche
,
J. C. Baker
,
+6 authors
S. Kasten
Progress in Nucleic Acid Research and Molecular…
2001
Corpus ID: 24455208
Highly Cited
1998
Highly Cited
1998
Isoenzymes of Pyruvate Dehydrogenase Phosphatase
Boli Huang
,
R. Gudi
,
Pengfei Wu
,
Robert A. Harris
,
J. Hamilton
,
K. M. Popov
Journal of Biological Chemistry
1998
Corpus ID: 686384
Pyruvate dehydrogenase phosphatase (PDP) is one of the few mammalian phosphatases residing within the mitochondrial matrix space…
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Highly Cited
1996
Highly Cited
1996
Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution.
A. Das
,
N. Helps
,
P. Cohen
,
D. Barford
EMBO Journal
1996
Corpus ID: 26649794
Protein phosphatase 2C (PP2C) is a Mn2+‐ or Mg2+‐dependent protein Ser/Thr phosphatase that is essential for regulating cellular…
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Highly Cited
1975
Highly Cited
1975
Regulation of pyruvate dehydrogenase kinase and phosphatase by acetyl-CoA/CoA and NADH/NAD ratios.
F. Pettit
,
J. Pelley
,
L. Reed
Biochemical and Biophysical Research…
1975
Corpus ID: 9847406
Highly Cited
1974
Highly Cited
1974
Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids.
S. Whitehouse
,
R. Cooper
,
P. J. Randle
Biochemical Journal
1974
Corpus ID: 537296
1. Monochloroacetate, dichloroacetate, trichloroacetate, difluoroacetate, 2-chloropropionate, 2,2'-dichloropropionate and 3…
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Highly Cited
1972
Highly Cited
1972
Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase.
R. Denton
,
P. J. Randle
,
B. Martin
Biochemical Journal
1972
Corpus ID: 2614698
In a number of mammalian tissues (heart, liver, kidney, fat-cells and brain), pyruvate dehydrogenase activity (EC 1.2.4.1) has…
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Highly Cited
1969
Highly Cited
1969
Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation.
T. C. Linn
,
F. Pettit
,
L. Reed
Proceedings of the National Academy of Sciences…
1969
Corpus ID: 19984659
This paper reports the discovery that the activity of the multienzyme pyruvate dehydrogenase complex from beef kidney…
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