Pyruvate Dehydrogenase (Lipoamide)-Phosphatase

Known as: Phosphatase, Pyruvate Dehydrogenase, PDH Phosphatase, Phosphatase, PDH 
(Pyruvate dehydrogenase (lipoamide))-phosphate phosphohydrolase. A mitochondrial enzyme that catalyzes the hydrolytic removal of a phosphate on a… (More)
National Institutes of Health

Related topics

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9 relations
In BloodPDP1 geneProcess of secretionantagonists & inhibitors
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Broader (1)

Phosphoric Monoester Hydrolases

Papers overview

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Highly Cited
2014
Highly Cited
2014
Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex.
Mitochondrial pyruvate dehydrogenase complex (PDC) is crucial for glucose homeostasis in mammalian cells. The current… (More)
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Highly Cited
2013
Highly Cited
2013
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
In response to tenacious stress signals, such as the unscheduled activation of oncogenes, cells can mobilize tumour suppressor… (More)
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Highly Cited
2008
Highly Cited
2008
The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle.
beta 1-3-Adrenoreceptor (AR)-deficient mice are unable to regulate energy expenditure and develop diet-induced obesity on a high… (More)
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Review
2001
Review
2001
Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms.
The mammalian pyruvate dehydrogenase complex (PDC) plays central and strategic roles in the control of the use of glucose-linked… (More)
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Highly Cited
2001
Highly Cited
2001
Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites.
The enzymic activity of the mammalian pyruvate dehydrogenase complex is regulated by the phosphorylation of three serine residues… (More)
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Highly Cited
1996
Highly Cited
1996
Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution.
Protein phosphatase 2C (PP2C) is a Mn2+- or Mg2+-dependent protein Ser/Thr phosphatase that is essential for regulating cellular… (More)
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Highly Cited
1995
Highly Cited
1995
Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney.
Two heat-stable protein inhibitors of protein phosphatase 2A (PP2A), tentatively designated I1PP2A and I2PP2A, have been purified… (More)
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Highly Cited
1974
Highly Cited
1974
Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids.
1. Monochloroacetate, dichloroacetate, trichloroacetate, difluoroacetate, 2-chloropropionate, 2,2'-dichloropropionate and 3… (More)
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Highly Cited
1972
Highly Cited
1972
Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase.
 
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Highly Cited
1969
Highly Cited
1969
Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation.
This paper reports the discovery that the activity of the multienzyme pyruvate dehydrogenase complex from beef kidney… (More)
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