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Pyroglutamate Hydrolase

Known as: 5-Oxoprolinase, Pyroglutamate Hydrolase [Chemical/Ingredient], Oxoprolinase 
Hydrolyzes pyroglutamic acid in the presence of ATP to glutamate plus ADP and inorganic phosphate. Deficiency leads to pyroglutamic acidurea.
National Institutes of Health

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5-oxoprolinase deficiency
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

Papers overview

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2010
2010
A futile cycle, formed between two ATP-dependant γ-glutamyl cycle enzymes, γ-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis?
Cystinosis, an inherited disease caused by a defect in the lysosomal cystine transporter (CTNS), is characterized by renal… 
2004
2004
Evidence that the y-glutamyl cycle functions in vivo using intracellular glutathione : Effects of amino acids and selective inhibition of enzymes ( ' y-glutamyl transpeptidase / 5-oxoproline…
The function of the y-glutamyl cycle was explored in in vivo studies in which amino acids and specific inhibitors of cycle… 
1999
1999
Purification and Characterization of a Novel 5-Oxoprolinase ( without ATP-Hydrolyzing Activity ) from Alcaligenes faecalis N-38 A
A novel type of 5-oxoprolinase was found in a cell extract of strain N-38A, which was later identified as Alcaligenes faecalis… 
1986
1986
Modulation of gamma-glutamyl cycle and glutathione levels in rat mammary gland explants.
The reduced glutathione levels and the enzymes gamma-glutamyl-transpeptidase, 5-oxoprolinase and gamma-glutamylcysteine… 
1986
1986
/sup 18/O-studies on the mechanism of action of 5-oxoprolinase
When the reaction catalyzed by bacterial 5-oxoprolinase was carried out to 80% of completion in /sup 18/O-enriched H/sub 2/O… 
1979
1979
Development of gamma-glutamylcysteine synthetase and oxoprolinase in rat kidney.
gamma-Glutamylcysteine synthetase is present in barely detectable amounts in foetal kidney. Its activity starts to increase in… 
1978
1978
Enzymes of the gamma-glutamyl cycle in 'aging' WI-38 fibroblasts and in HeLa S3 cells.
gamma-Glutamyltransferase ((5-glutamyl)-peptide:amino-acid 5-glutamyltransferase, EC 2.3.2.2) activity of WI-38 fibroblasts… 
1976
1976
Assay of pyroglutamate hydrolase (5-oxoprolinase) in tissue homogenates.
1975
1975
5-Oxoprolinase from rat kidney, I. Assay, purification, and determination of kinetic parameters.
A new assay for the determination of 5-oxoprolinase activity is described. The enzyme 5-oxoprolinase was purified from rat kidney… 
1975
1975
5-Oxoprolinase from rat kidney, II. Molecular weight determinations.
The molecular weight of 5-oxoprolinase from rat kidney was estimated by gel filtration on Sephadex G-200 and G-150 to be 460 000… 
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