Pyrithiamine

Known as: Neopyrithiamine, Pyrithiamine [Chemical/Ingredient], Pyridinium, 1-((4-amino-2-methyl-5-pyrimidinyl)methyl)-3-(2-hydroxyethyl)-2-methyl-, bromide, monohydrobromide 
A thiamine antagonist due to its inhibition of thiamine pyrophosphorylation. It is used to produce thiamine deficiency.
National Institutes of Health

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Highly Cited
2007
Highly Cited
2007
In bacteria, many genes involved in the biosynthesis of cofactors such as thiamine pyrophosphate (TPP) are regulated by ribo… (More)
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Highly Cited
2006
Highly Cited
2006
Riboswitches are metabolite-sensing RNAs, typically located in the non-coding portions of messenger RNAs, that control the… (More)
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Highly Cited
2006
Highly Cited
2006
Riboswitches are noncoding mRNA elements that bind small-molecule metabolites with high affinity and specificity, and they… (More)
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Highly Cited
2005
Highly Cited
2005
Thiamine metabolism genes are regulated in numerous bacteria by a riboswitch class that binds the coenzyme thiamine pyrophosphate… (More)
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2002
2002
A pyrithiamine (PT) resistance gene (ptrA) was cloned from a PT resistant mutant of Aspergillus oryzae and was useful as a… (More)
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1995
1995
Pyrithiamine-induced thiamine deficiency (PTD) in rats is used to model the etiology, diencephalic neuropathology, and memory… (More)
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1991
1991
Alterations of excitatory amino acids in brain may be of pathophysiological significance in thiamine-deficiency encephalopathy… (More)
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1990
1990
An acute bout of pyrithiamine-induced thiamine deficiency (PTD) produces pathologic lesions within thalamus, mammillary body, and… (More)
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1988
1988
Rats were subjected to a severe bout of thiamine deficiency induced by daily pyrithiamine +a thiamine deficient diet, reversed by… (More)
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1978
1978
Pyrithiamine induced acute thiamine deficient encephalopathy in the mouse is one of the possible animal models of human Wernicke… (More)
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