Pyrimethamine / Sulfadoxine

Known as: PYRIMETHAMINE/SULFADOXINE, sulphadoxine-pyrimethamine, fanasil, pyrimethamine drug combination 
A combination product containing pyrimethamine and sulfadoxine. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a… (More)
National Institutes of Health

Papers overview

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Review
2007
Review
2007
Artemisinin-based combination treatments (ACTs) are now generally accepted as the best treatments for uncomplicated falciparum… (More)
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Highly Cited
2005
Highly Cited
2005
The emergence and spread of multidrug resistant Plasmodium falciparum has severely limited the therapeutic options for the… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Many countries in Africa are considering a change to combination treatment for falciparum malaria because of the… (More)
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Highly Cited
2003
Highly Cited
2003
In 1993, Malawi became the first African country to replace chloroquine with sulfadoxine-pyrimethamine nationwide in response to… (More)
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Highly Cited
2002
Highly Cited
2002
Molecular assays for monitoring sulfadoxine-pyrimethamine-resistant Plasmodium falciparum have not been implemented because of… (More)
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Highly Cited
2002
Highly Cited
2002
The malaria vaccine Combination B comprises recombinant Plasmodium falciparum ring-infected erythrocyte surface antigen and 2… (More)
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Highly Cited
2002
Highly Cited
2002
The Calgary Biofilm Device (CBD) was used to form bacterial biofilms of selected veterinary gram-negative and gram-positive… (More)
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Highly Cited
2001
Highly Cited
2001
Combination therapy that includes artemisinin derivatives cures most falciparum malaria infections. Lowering transmission by… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND In areas of endemic transmission, malaria in pregnancy is associated with severe maternal anaemia and low-birthweight… (More)
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Highly Cited
1998
Highly Cited
1998
A fever case management (CM) approach using sulfadoxine-pyrimethamine (SP) was compared with two presumptive intertmittent SP… (More)
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