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Purinergic Antagonists

Known as: Purinoceptor Antagonists, Antagonists, Purinergic, Purinergic Receptor Antagonists 
Drugs that bind to and block the activation of PURINERGIC RECEPTORS.
National Institutes of Health

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Papers overview

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Highly Cited
2007
Highly Cited
2007
P19 embryonal carcinoma cells as in vitro model for studying purinergic receptor expression and modulation of N-methyl-d-aspartate–glutamate and acetylcholine receptors during neuronal…
Highly Cited
2006
Highly Cited
2006
ATP Stimulates Mouse Embryonic Stem Cell Proliferation via Protein Kinase C, Phosphatidylinositol 3‐Kinase/Akt, and Mitogen‐Activated Protein Kinase Signaling Pathways
This study investigated the effect of ATP and its related signal cascades on the proliferation of mouse ESCs. ATP increased the… 
2006
2006
Local regulation of skin blood flow during cooling involving presynaptic P2 purinoceptors in rats
1 This study investigated a local effect of cooling on the plantar skin blood flow (PSBF) of tetrodotoxin‐treated rats by laser… 
2002
2002
Complementary role of extracellular ATP and adenosine in ischemic preconditioning in the rat heart.
Although adenosine is an important mediator of ischemic preconditioning (IPC), its relative contribution to IPC remains unknown… 
Highly Cited
1998
Highly Cited
1998
Purinergic Receptor Modulation of Lipopolysaccharide Signaling and Inducible Nitric-oxide Synthase Expression in RAW 264.7 Macrophages*
Previous studies have suggested that the P2Z/P2X7 purinergic receptor can participate in nucleotide-induced modulation of… 
Highly Cited
1996
Highly Cited
1996
The P2Y purinoceptor in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase
1 BIO cells, a clonal line of rat brain capillary endothelial cells, exhibit a single P2 purinoceptor, activation of which leads… 
1996
1996
A comparison of the binding characteristics of recombinant P2×1 and P2×2 purinoceptors
1 . We have recently provided evidence that [35S]‐adenosine 5′‐O‐[3‐thiotriphosphate] ([35S]‐ATPγS) can label the human bladder… 
Highly Cited
1996
Highly Cited
1996
Purinoceptor modulation of noradrenaline release in rat tail artery: tonic modulation mediated by inhibitory P2Y‐ and facilitatory A2A‐purinoceptors
1 The effects of analogues of adenosine and ATP on noradrenaline release elicited by electrical stimulation (5 Hz, 2700 pulses… 
Highly Cited
1996
Highly Cited
1996
Neuronal mediators of inhibitory junction potentials and relaxation in the guinea‐pig internal anal sphincter.
1. Inhibitory junction potentials (IJPs) and relaxations evoked in response to field stimulation (supramaximal voltage, 0.1 ms… 
1993
1993
ATP and endogenous agonists inhibit evoked [3H]-noradrenaline release in rat iris via A1 and P2y-like purinoceptors
SummaryEffects of ATP, adenosine and purinoceptor antagonists on field stimulation-evoked (3 Hz, 2 min) [3H]-noradrenaline… 
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