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Purine Nucleoside Phosphorylase Inhibitor

Any substance that inhibits purine nucleoside phosphorylase, an enzyme involved in the purine salvage pathway that metabolizes adenosine into adenine… Expand
National Institutes of Health

Papers overview

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2010
2010
The profound suppression of T-cell immunity seen in purine nucleoside phosphorylase (PNP; EC 2.4.2.1) deficient patients supports… Expand
Highly Cited
2005
Highly Cited
2005
The discovery of purine nucleoside phosphorylase (PNP) deficiency and T lymphocytopenia suggested that inhibition of this enzyme… Expand
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Highly Cited
2003
Highly Cited
2003
[reaction: see text] The expeditious convergent synthesis of the potent human purine nucleoside phosphorylase inhibitor DADMe… Expand
Highly Cited
2002
Highly Cited
2002
In the brain, the levels of adenosine increase up to 100-fold during cerebral ischernia; however, the roles of specific cell… Expand
2000
2000
The pharmacokinetic parameters of peldesine (BCX‐34) were investigated after single and multiple oral doses in two groups of… Expand
Highly Cited
1999
Highly Cited
1999
Murine spinal cord primary mixed cultures were treated with the respiratory inhibitor, rotenone, to mimic hypoxic conditions… Expand
1998
1998
The antiproliferative effect of BCX-34 was tested in normal human peripheral blood mononuclear cells (PBMCs) induced to… Expand
1996
1996
BCX-34 inhibits RBC PNP in vitro from humans, rats, and mice with IC50S ranging from 5 to 36 nM. BCX-34 also, in the presence but… Expand
1991
1991
CI-972 (2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2- d]pyrimidin-4-one monohydrochloride, monohydrate) is a… Expand
Highly Cited
1988
Highly Cited
1988
When thymocytes were cultured with adenosine, deoxyadenosine, or deoxyguanosine at 1 mM for 24 h, DNA cleavage at… Expand