Purine Nucleoside Phosphorylase Inhibitor

Any substance that inhibits purine nucleoside phosphorylase, an enzyme involved in the purine salvage pathway that metabolizes adenosine into adenine… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1985-2017
012319852017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
The profound suppression of T-cell immunity seen in purine nucleoside phosphorylase (PNP; EC 2.4.2.1) deficient patients supports… (More)
Is this relevant?
2009
2009
Forodesine HCl is being investigated as a potential therapeutic target for the control of T-cell proliferation. During the filing… (More)
  • figure 1
  • figure 2
Is this relevant?
2005
2005
The discovery of purine nucleoside phosphorylase (PNP) deficiency and T lymphocytopenia suggested that inhibition of this enzyme… (More)
  • table 1
  • table 2
  • figure 2
  • table 3
  • figure 3
Is this relevant?
2003
2003
[reaction: see text] The expeditious convergent synthesis of the potent human purine nucleoside phosphorylase inhibitor DADMe… (More)
Is this relevant?
2002
2002
In the brain, the levels of adenosine increase up to 100-fold during cerebral ischernia; however, the roles of specific cell… (More)
Is this relevant?
2000
2000
The pharmacokinetic parameters of peldesine (BCX-34) were investigated after single and multiple oral doses in two groups of… (More)
Is this relevant?
1998
1998
The antiproliferative effect of BCX-34 was tested in normal human peripheral blood mononuclear cells (PBMCs) induced to… (More)
Is this relevant?
1995
1995
Rats received daily oral doses of 15, 50, 150, or 200 mg/kg CI-1000 for 4 weeks. Doses were selected based on findings from a 2… (More)
Is this relevant?
1991
1991
CI-972 (2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2- d]pyrimidin-4-one monohydrochloride, monohydrate) is a… (More)
Is this relevant?
1987
1987
PD 119,229 [8-amino-9-(2-thienylmethyl)guanine] is a novel and potent inhibitor of human erythrocyte purine nucleoside… (More)
  • figure 1
  • table 1
Is this relevant?