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Purine Nucleoside Phosphorylase Inhibitor

Any substance that inhibits purine nucleoside phosphorylase, an enzyme involved in the purine salvage pathway that metabolizes adenosine into adenine… 
National Institutes of Health

Papers overview

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Review
2013
Review
2013
2012
2012
ATL is a distinct peripheral T-lymphocytic malignancy associated with human T-cell lymphotropic virus type I (HTLV-1). The… 
Highly Cited
2010
Highly Cited
2010
Forodesine, a purine nucleoside phosphorylase inhibitor, displays in vitro activity in chronic lymphocytic leukemia (CLL) cells… 
Highly Cited
2005
Highly Cited
2005
The discovery of purine nucleoside phosphorylase (PNP) deficiency and T lymphocytopenia suggested that inhibition of this enzyme… 
2000
2000
The pharmacokinetic parameters of peldesine (BCX‐34) were investigated after single and multiple oral doses in two groups of… 
Highly Cited
1988
Highly Cited
1988
When thymocytes were cultured with adenosine, deoxyadenosine, or deoxyguanosine at 1 mM for 24 h, DNA cleavage at…