Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Purine Nucleoside Phosphorylase Inhibitor

Any substance that inhibits purine nucleoside phosphorylase, an enzyme involved in the purine salvage pathway that metabolizes adenosine into adenine… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
The profound suppression of T-cell immunity seen in purine nucleoside phosphorylase (PNP; EC 2.4.2.1) deficient patients supports… Expand
Is this relevant?
2010
2010
Forodesine, a purine nucleoside phosphorylase inhibitor, displays in vitro activity in chronic lymphocytic leukemia (CLL) cells… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2005
2005
The discovery of purine nucleoside phosphorylase (PNP) deficiency and T lymphocytopenia suggested that inhibition of this enzyme… Expand
  • table 1
  • table 2
  • figure 2
  • table 3
  • figure 3
Is this relevant?
2005
2005
PD 119,229 [8-amino-9-(2-thienylmethyl)guanine] is a novel and potent inhibitor of human erythrocyte purine nucleoside… Expand
  • figure 1
  • table 1
Is this relevant?
2003
2003
[reaction: see text] The expeditious convergent synthesis of the potent human purine nucleoside phosphorylase inhibitor DADMe… Expand
Is this relevant?
2002
2002
In the brain, the levels of adenosine increase up to 100-fold during cerebral ischernia; however, the roles of specific cell… Expand
Is this relevant?
2000
2000
The pharmacokinetic parameters of peldesine (BCX-34) were investigated after single and multiple oral doses in two groups of… Expand
Is this relevant?
1999
1999
Murine spinal cord primary mixed cultures were treated with the respiratory inhibitor, rotenone, to mimic hypoxic conditions… Expand
Is this relevant?
1998
1998
The antiproliferative effect of BCX-34 was tested in normal human peripheral blood mononuclear cells (PBMCs) induced to… Expand
Is this relevant?
1991
1991
CI-972 (2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2- d]pyrimidin-4-one monohydrochloride, monohydrate) is a… Expand
Is this relevant?