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Pteridinones

Pteridines with a 4-keto OXYGEN.
National Institutes of Health

Papers overview

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2020
2020
The data have been obtained for a series of substituted pteridinones and pyrimidines that were developed based on BI-D1870 to… Expand
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2020
2020
The activity of p90 ribosomal S6 kinase 2 (RSK2) has emerged as an attractive target for cancer therapy due to its role in the… Expand
2018
2018
A new synthetic protocol for nucleophilic substitution of hydrogen­ in quinoxalones and pteridinones by the action of 5,7-di… Expand
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2010
2010
Pteridinones were designed based on a non-selective kinase template. Because of the uniqueness of the PI3K and mTOR binding… Expand
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2005
2005
L'invention concerne des composes de formule generale (I), dans laquelle L, Q1, Q2, X, Y, Ra, Rb, Rc, R1, R2, R3 et R4 sont tels… Expand
1993
1993
The introduction of fluorine into molecules has been well demonstrated to modify the biological properties significantly1. In… Expand