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Proximal Interphalangeal Joint 4

Known as: PIP4 
A ginglymoid (hinge) synovial joint within the fourth digit of the hand or foot connecting the proximal and middle phalanges.
National Institutes of Health

Related topics

Related topics

4 relations
Body partCDISC SDTM Anatomical Location TerminologyClinical Data Interchange Standards Consortium TerminologySkeletal system

Papers overview

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2019
2019
Phosphatidylinositol 5 Phosphate 4-Kinase Regulates Plasma-Membrane PIP3 Turnover and Insulin Signaling
Phosphatidylinositol 3,4,5-trisphosphate (PIP3) generation at the plasma membrane is a key event during activation of receptor… Expand
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2019
2019
Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p
The heterodimeric eukaryotic Drs2p-Cdc50p complex is a lipid flippase that maintains cell membrane asymmetry. The enzyme complex… Expand
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2019
2019
Novel Molecular Signatures in the PIP4K/PIP5K Family of Proteins Specific for Different Isozymes and Subfamilies Provide Important Insights into the Evolutionary Divergence of this Protein Family
Members of the PIP4K/PIP5K family of proteins, which generate the highly important secondary messenger phosphatidylinositol-4,5… Expand
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2017
2017
Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
Achieving robust cancer-specific lethality is the ultimate clinical goal. Here, we identify a compound with dual-inhibitory… Expand
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2017
2017
Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein
The discovery of the causative gene for Huntington's disease (HD) has promoted numerous efforts to uncover cellular pathways that… Expand
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2017
2017
Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics during clathrin-mediated endocytosis
Endocytic turnover is essential for the regulation of the protein composition and function of the plasma membrane, and thus… Expand
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2013
2013
Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development.
During development, Drosophila larvae undergo a dramatic increase in body mass wherein nutritional and developmental cues are… Expand
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2012
2012
Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stress.
Oxidative signaling and oxidative stress contribute to aging, cancer, and diseases resulting from neurodegeneration. Pin1 is a… Expand
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2010
2010
PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha.
The beta-isoform of PIP4K (PtdIns5P-4-kinase) regulates the levels of nuclear PtdIns5P, which in turn modulates the acetylation… Expand
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Highly Cited
2003
Highly Cited
2003
The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation.
Phosphatidylinositol-5-phosphate (PI-5-P) is a newly identified phosphoinositide with characteristics of a signaling lipid but no… Expand
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