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Protein-tyrosine kinase inhibitor

Known as: Tyrosine Kinase Inhibitor, TK Inhibitors, Protein Tyrosine Kinase Inhibitors 
Any substance that inhibits tyrosine kinase, an enzyme involved in the transduction and processing of many extracellular and intracellular signals… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Using MRI techniques, we show here that normalization of tumor vessels in recurrent glioblastoma patients by daily administration… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which… Expand
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Highly Cited
2003
Highly Cited
2003
CONTEXT More persons in the United States die from non-small cell lung cancer (NSCLC) than from breast, colorectal, and prostate… Expand
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Highly Cited
2003
Highly Cited
2003
One challenging aspect in the clinical development of molecularly targeted therapies, which represent a new and promising… Expand
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Highly Cited
2002
Highly Cited
2002
Through sequencing analysis of blood or bone marrow samples from patients with chronic myeloid leukemia, we identified BCR-ABL… Expand
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Highly Cited
2001
Highly Cited
2001
BACKGROUND BCR-ABL, a constitutively activated tyrosine kinase, is the product of the Philadelphia chromosome. This enzyme is… Expand
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Highly Cited
2001
Highly Cited
2001
Gastrointestinal stromal tumors are a group of mesenchymal neoplasms that arise from precursors of the connective-tissue cells of… Expand
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Highly Cited
2000
Highly Cited
2000
STI571 (formerly known as CGP 57148B) is a protein-tyrosine kinase inhibitor that is currently in clinical trials for the… Expand
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Highly Cited
1996
Highly Cited
1996
Here, we have studied the activity of a novel protein-tyrosine kinase inhibitor that is selective for the Src family of tyrosine… Expand
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Highly Cited
1994
Highly Cited
1994
Phosphatidylinositol (PtdIns) 3-kinase is an enzyme implicated in growth factor signal transduction by associating with receptor… Expand
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