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Protein-tyrosine kinase inhibitor
Known as:
Tyrosine Kinase Inhibitor
, TK Inhibitors
, Protein Tyrosine Kinase Inhibitors
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Any substance that inhibits tyrosine kinase, an enzyme involved in the transduction and processing of many extracellular and intracellular signals…
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National Institutes of Health
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Related topics
Related topics
3 relations
Receptor Tyrosine Kinase Inhibition
Tyrosine Kinase Inhibitors [MoA]
protein tyrosine kinase inhibitor activity
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib.
J. Woyach
,
R. Furman
,
+22 authors
J. Byrd
New England Journal of Medicine
2014
Corpus ID: 5379962
BACKGROUND Ibrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (BTK) and is effective in chronic lymphocytic…
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Highly Cited
2011
Highly Cited
2011
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase…
Caicun Zhou
,
Yi-long Wu
,
+20 authors
C. You
The Lancet Oncology
2011
Corpus ID: 11704864
Highly Cited
2010
Highly Cited
2010
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial…
T. Mitsudomi
,
S. Morita
,
+18 authors
M. Fukuoka
The Lancet Oncology
2010
Corpus ID: 26257413
Highly Cited
2002
Highly Cited
2002
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors.
G. Demetri
,
M. von Mehren
,
+18 authors
H. Joensuu
New England Journal of Medicine
2002
Corpus ID: 46098916
BACKGROUND Constitutive activation of KIT receptor tyrosine kinase is critical in the pathogenesis of gastrointestinal stromal…
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Highly Cited
2000
Highly Cited
2000
Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors.
E. Buchdunger
,
C. Cioffi
,
+4 authors
N. Lydon
Journal of Pharmacology and Experimental…
2000
Corpus ID: 890591
STI571 (formerly known as CGP 57148B) is a protein-tyrosine kinase inhibitor that is currently in clinical trials for the…
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Highly Cited
2000
Highly Cited
2000
Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor.
M. Heinrich
,
D. Griffith
,
B. Druker
,
C. Wait
,
Kristen A. Ott
,
A. J. Zigler
Blood
2000
Corpus ID: 6866146
STI 571 (formerly known as CGP 57148B) is a known inhibitor of the c-abl, bcr-abl, and platelet-derived growth-factor receptor…
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Review
2000
Review
2000
Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia.
B. Druker
,
N. Lydon
Journal of Clinical Investigation
2000
Corpus ID: 10490735
Protein kinases are a large family of homologous proteins comprising 2 major subfamilies, the protein serine/threonine kinases…
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Highly Cited
1997
Highly Cited
1997
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
M. Mohammadi
,
G. Mcmahon
,
+5 authors
J. Schlessinger
Science
1997
Corpus ID: 26856676
A new class of protein tyrosine kinase inhibitors was identified that is based on an oxindole core (indolinones). Two compounds…
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Highly Cited
1996
Highly Cited
1996
Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor
J. Hanke
,
J. Gardner
,
+5 authors
P. Connelly
Journal of Biological Chemistry
1996
Corpus ID: 29832169
Here, we have studied the activity of a novel protein-tyrosine kinase inhibitor that is selective for the Src family of tyrosine…
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Highly Cited
1994
Highly Cited
1994
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
C. Vlahos
,
W. Matter
,
K. Hui
,
R. F. Brown
Journal of Biological Chemistry
1994
Corpus ID: 19752008
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